{"id":"W4387297227","doi":"10.1002/cpt.3068","title":"Nicotine Metabolite Ratio Decreases After Switching Off Efavirenz‐Based Therapy in People With <scp>HIV</scp> Who Smoke","year":2023,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"HIV/AIDS Research and Interventions","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Institute of Mental Health; Center for AIDS Research, University of Washington; Canada Research Chairs; University of Washington; Canadian Institutes of Health Research; Penn Mental Health AIDS Research Center; Cambia Health Foundation; National Institute on Alcohol Abuse and Alcoholism; University of Pennsylvania","keywords":"Efavirenz; CYP2A6; Cotinine; Regimen; Chemistry; Metabolite; Human immunodeficiency virus (HIV); Nicotine; Emtricitabine; Antiretroviral therapy; Pharmacology; Medicine; Internal medicine; Viral load; CYP3A4; Virology; Metabolism; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003626418,0.0001496125,0.0003388979,0.000359157,0.0002636751,0.000536775,0.0001903652,0.0004760307,0.001608026],"category_scores_gemma":[0.00148265,0.0002069031,0.0003500609,0.0003730532,0.0001490259,0.0003563515,0.0002567042,0.0006216594,0.0002968484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002662981,"about_ca_system_score_gemma":0.0001763931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004031335,"about_ca_topic_score_gemma":0.005050127,"domain_scores_codex":[0.9997583,0.00004983157,0.00002447859,0.00006397317,0.00004869217,0.00005466048],"domain_scores_gemma":[0.9993488,0.0001224444,0.0002952676,0.00003997545,0.00007178193,0.0001217079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001757296,0.0002889991,0.985468,0.00002379638,0.000103067,0.0001260217,0.0001915957,0.00003323095,0.002051505,0.00001533494,0.0001486711,0.009792453],"study_design_scores_gemma":[0.00001018855,0.0002834753,0.9991459,0.000002951758,0.00002497066,0.0001232769,0.00007782928,0.00008127956,0.0001528418,0.00001075619,0.00008446573,0.000002206954],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992214,0.0001473639,0.00002940954,0.00002628131,0.000004537901,0.000006392805,0.0001606652,0.000003521189,0.0004003857],"genre_scores_gemma":[0.9993339,0.00005784174,0.00004351118,0.00003832948,0.000005601807,0.000007083847,0.0001725647,0.000001447008,0.0003396121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004031335,"threshold_uncertainty_score":0.008015752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08329523741160537,"score_gpt":0.4370782495152845,"score_spread":0.3537830121036791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}