{"id":"W4387300006","doi":"10.21203/rs.3.rs-3258813/v1","title":"Lithium Response in Bipolar Disorder is Associated with Focal Adhesion and PI3K-Akt Networks: A Multi-omics Replication Study","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Douglas Mental Health University Institute; McGill University; McGill University Health Centre; Dalhousie University","funders":"Medical Research Council; Alfried Krupp von Bohlen und Halbach-Stiftung; National Institute of Mental Health; Vetenskapsrådet; Deutsche Forschungsgemeinschaft; University of California, San Diego; Rheinische Friedrich-Wilhelms-Universität Bonn; Bundesministerium für Bildung und Forschung; National Alliance for Research on Schizophrenia and Depression; National Health and Medical Research Council; Karolinska Institutet; Brain and Behavior Research Foundation","keywords":"Replication (statistics); Lithium (medication); PI3K/AKT/mTOR pathway; Focal adhesion; Bipolar disorder; Protein kinase B; Computational biology; Biology; Psychology; Cell biology; Psychiatry; Virology; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002675103,0.0009089148,0.00136668,0.0006930633,0.001427013,0.00223411,0.001018355,0.001384013,0.004867288],"category_scores_gemma":[0.008850893,0.0005729289,0.002126884,0.001511364,0.0005915784,0.0007409398,0.001237691,0.001266118,0.0009185882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001027253,"about_ca_system_score_gemma":0.001215635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01304623,"about_ca_topic_score_gemma":0.01521435,"domain_scores_codex":[0.9979518,0.0007103583,0.0001835843,0.0006499603,0.0002554629,0.0002489326],"domain_scores_gemma":[0.9965633,0.0007085711,0.0009783616,0.0008460581,0.0007046303,0.0001991979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01041963,0.0003372711,0.9154689,0.001221516,0.01120989,0.0009874736,0.001425939,0.0003998736,0.01665879,0.0008738796,0.009568764,0.03142811],"study_design_scores_gemma":[0.0008019739,0.0005857085,0.9813437,0.0001940766,0.005867458,0.0009351356,0.0008995882,0.0005164208,0.001584657,0.001204915,0.005993749,0.00007248308],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9751031,0.004990189,0.002678819,0.00113783,0.0002113819,0.0002635727,0.01299711,0.00008411558,0.002533895],"genre_scores_gemma":[0.9839511,0.0009145093,0.002468638,0.0008645768,0.0001028712,0.0005225333,0.009145465,0.00009423425,0.001936077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01304623,"threshold_uncertainty_score":0.0259406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08846814945559298,"score_gpt":0.4078094525724943,"score_spread":0.3193413031169013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}