{"id":"W4387300260","doi":"10.1093/rheumatology/kead493","title":"Inhibition of TLR4 signalling to dampen joint inflammation in osteoarthritis","year":2023,"lang":"en","type":"review","venue":"Lara D. Veeken","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 European Research Council; Dutch Arthritis Society; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; ZonMw; European Commission; Arthritis Society","keywords":"TLR4; Inflammation; Medicine; Pattern recognition receptor; Osteoarthritis; Receptor; Signalling; Innate immune system; HMGB1; Toll-like receptor; Immunology; Immune system; Signal transduction; Cell biology; Biology; Internal medicine; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008412308,0.0003026684,0.001284404,0.0007990167,0.00006299104,0.00002141544,0.0001800117,0.000657743,0.0001474695],"category_scores_gemma":[0.0002600173,0.0002959756,0.0002840259,0.0006022005,0.00004566821,0.0001575514,0.0001502628,0.00044481,0.00324165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001215812,"about_ca_system_score_gemma":0.0001742747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007401463,"about_ca_topic_score_gemma":0.00008307942,"domain_scores_codex":[0.9974174,0.0005579062,0.001283049,0.0003375345,0.00006983374,0.0003342433],"domain_scores_gemma":[0.9988532,0.0002233129,0.0004979232,0.0003260539,0.00008074774,0.0000187491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006889782,0.00002656835,0.000001847016,0.004607336,0.0001204328,0.00002057731,0.0005887809,0.00001668345,0.0416509,0.0002897206,0.0004134127,0.9521949],"study_design_scores_gemma":[0.0007027611,0.0002286431,0.00004163589,0.02354179,0.0001524138,0.00003069119,0.00006041268,0.000001206713,0.01907051,0.000131718,0.9556499,0.0003883127],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007142724,0.99009,0.00008774291,0.00005370893,0.0004626484,0.001501675,0.0000538798,0.00009345709,0.0005142362],"genre_scores_gemma":[0.0006983732,0.9957352,0.00004438617,0.00001418486,0.00008999464,0.0002742851,0.001770167,0.00005863798,0.001314747],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9552365,"threshold_uncertainty_score":0.9999492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04023589370884667,"score_gpt":0.2880796331914985,"score_spread":0.2478437394826519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}