{"id":"W4387301575","doi":"10.1016/j.nmd.2023.07.489","title":"O20 Safety and efficacy of intravenous onasemnogene abeparvovec in patients with spinal muscular atrophy: interim findings from the phase 3 SMART study","year":2023,"lang":"en","type":"article","venue":"Neuromuscular Disorders","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's Hospital of Eastern Ontario","funders":"","keywords":"Spinal muscular atrophy; Interim; Medicine; Interim analysis; Physical medicine and rehabilitation; Anesthesia; Internal medicine; Clinical trial; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003354318,0.000349041,0.0005826818,0.0002699429,0.0001465616,0.00003176293,0.0003051763,0.00008204749,0.00006316414],"category_scores_gemma":[0.0002239285,0.0002503157,0.0001921946,0.0009847494,0.0003183879,0.00006286905,0.0002334077,0.0004399143,0.00002154431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000342263,"about_ca_system_score_gemma":0.0001099644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006427307,"about_ca_topic_score_gemma":0.0002955771,"domain_scores_codex":[0.9970059,0.0002984906,0.000499631,0.0007460112,0.0009139948,0.0005359633],"domain_scores_gemma":[0.9986875,0.0001469261,0.00009086264,0.0008002704,0.00009007022,0.0001843509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008975426,0.006503987,0.912828,0.0001447761,0.0006451978,0.0002251258,0.002364492,0.0001065484,0.00324256,0.00001447219,0.00009271962,0.06485673],"study_design_scores_gemma":[0.02428534,0.006491952,0.9663221,0.00009852746,0.0002373112,0.000003092329,0.0007922024,0.0001288806,0.0001691015,0.00002223527,0.001223979,0.0002252867],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960242,0.0003833894,0.00006985182,0.0006381363,0.00008291432,0.002644075,0.00003811991,0.00005646034,0.00006283682],"genre_scores_gemma":[0.9989665,0.0004886292,0.00003704262,0.0001843355,0.00002460835,0.00005244501,0.0001456954,0.00008055216,0.00002026226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06463144,"threshold_uncertainty_score":0.9999949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01343045729391163,"score_gpt":0.2878684352970213,"score_spread":0.2744379780031097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}