{"id":"W4387306433","doi":"10.1016/j.nmd.2023.07.040","title":"P59 Generation and characterization of a novel XMEA mouse model and pharmacological evaluation of autophagy antagonists","year":2023,"lang":"en","type":"article","venue":"Neuromuscular Disorders","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Amgen (Canada); University of Toronto; Hospital for Sick Children","funders":"","keywords":"Autophagy; Characterization (materials science); Pharmacology; Chemistry; Biology; Nanotechnology; Materials science; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002971955,0.00009863944,0.0001813157,0.0001065888,0.00004238182,0.000006398095,0.00003055552,0.00006217354,0.00001959548],"category_scores_gemma":[0.00005674648,0.00009012523,0.00004915238,0.000164957,0.00008154604,0.0000814277,0.00002441348,0.0000557097,6.876267e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001200717,"about_ca_system_score_gemma":0.00007266773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005236975,"about_ca_topic_score_gemma":0.000001794882,"domain_scores_codex":[0.999016,0.00006011712,0.0002013737,0.0002094635,0.000411366,0.0001017019],"domain_scores_gemma":[0.999599,0.00001354743,0.00009300609,0.0001173548,0.0001198065,0.00005726185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00006805914,0.0002115986,0.0006999142,0.00006643631,0.00005433173,8.1596e-7,0.0002169269,0.001181697,0.9893617,0.0001051879,0.00001330134,0.008020041],"study_design_scores_gemma":[0.003202436,0.000158935,0.1038596,0.00001075448,0.0002805662,0.000002460115,0.00001927663,0.7766691,0.1156029,0.00008936085,0.00002855327,0.0000759771],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980975,0.0001513098,0.0008137472,0.0002585161,0.00004874853,0.000517102,0.00003145857,0.00004297414,0.00003869185],"genre_scores_gemma":[0.9981328,0.001356128,0.00009002356,0.0001550341,0.00002500337,0.00003480622,0.0001567999,0.00001620009,0.00003323692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8737587,"threshold_uncertainty_score":0.36752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05744731327494706,"score_gpt":0.3287121939881695,"score_spread":0.2712648807132225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}