{"id":"W4387306433","doi":"10.1016/j.nmd.2023.07.040","title":"P59 Generation and characterization of a novel XMEA mouse model and pharmacological evaluation of autophagy antagonists","year":2023,"lang":"en","type":"article","venue":"Neuromuscular Disorders","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Amgen (Canada); University of Toronto; Hospital for Sick Children","funders":"","keywords":"Autophagy; Characterization (materials science); Pharmacology; Chemistry; Biology; Nanotechnology; Materials science; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006912384,0.001319241,0.0007926346,0.001815115,0.0007106061,0.0008154429,0.000890982,0.001628922,0.005328815],"category_scores_gemma":[0.0002568208,0.0004409779,0.001131366,0.0005140253,0.0009847868,0.0009674121,0.0004873624,0.002754321,0.001872882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000611375,"about_ca_system_score_gemma":0.0004725343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000745012,"about_ca_topic_score_gemma":0.001427273,"domain_scores_codex":[0.9994076,0.00005063775,0.00008514181,0.0001736288,0.0001664352,0.0001164197],"domain_scores_gemma":[0.9997157,0.00003179246,0.00009295482,0.00003592714,0.00003936687,0.00008420127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003876933,0.0002201169,0.0001640341,0.0000783916,0.00002195757,0.0002615177,0.00003874398,0.000101884,0.9955086,0.0008732988,0.0002958547,0.002047903],"study_design_scores_gemma":[0.0001899853,0.0009946387,0.001872509,0.00005885667,0.0001186876,0.001148028,0.00009870833,0.00118469,0.9803074,0.0003923129,0.01361447,0.00001964189],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9137844,0.005877994,0.05633118,0.001743005,0.0009258452,0.001245099,0.009815785,0.001203948,0.009072755],"genre_scores_gemma":[0.8879522,0.007968703,0.04559822,0.0009236793,0.0001921501,0.002540827,0.009118771,0.0005851627,0.04512034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005328815,"threshold_uncertainty_score":0.01782662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05744731327494706,"score_gpt":0.3287121939881695,"score_spread":0.2712648807132225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}