{"id":"W4387306750","doi":"10.3389/fendo.2023.1261298","title":"Insulin and aging – a disappointing relationship","year":2023,"lang":"en","type":"review","venue":"Frontiers in Endocrinology","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Heinrich-Heine-Universität Düsseldorf; Ottawa Hospital Research Institute; University of Ottawa","keywords":"Insulin resistance; Insulin; Hyperinsulinemia; Endocrinology; Internal medicine; Oxidative stress; Insulin receptor; Anabolism; Biology; Lipogenesis; Medicine; Lipid metabolism","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002115578,0.0003846025,0.0009303873,0.0003778298,0.00009726052,0.00003121667,0.000334514,0.0004450532,0.00000329879],"category_scores_gemma":[0.0003213389,0.0003991967,0.0001722538,0.0002282299,0.0002005565,0.000003564852,0.0004147548,0.00050771,0.00002665252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004396272,"about_ca_system_score_gemma":0.0001217051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002691485,"about_ca_topic_score_gemma":0.00005310825,"domain_scores_codex":[0.9977723,0.0002504184,0.000561098,0.0007345186,0.00009214394,0.0005895155],"domain_scores_gemma":[0.9991472,0.00005727689,0.0002169272,0.0004769329,0.0000237744,0.00007788285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001012516,0.00005097129,0.01125802,0.006037965,0.0003115885,0.0000986571,0.0003771282,0.00003236433,0.00001564961,0.0003887756,0.00646976,0.974949],"study_design_scores_gemma":[0.0003518681,0.0000637722,0.0004751392,0.0008373854,0.0001936638,0.0001359875,0.0001387137,0.00003102557,0.00001428837,0.0008585674,0.9963976,0.0005019788],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006733256,0.994055,0.003347194,0.00005994706,0.001152138,0.0004135027,0.00002339836,0.00004707089,0.000228435],"genre_scores_gemma":[0.0007017155,0.9930665,0.004335144,0.00005011484,0.0003295867,0.00008924649,0.0002493314,0.0001026145,0.001075674],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9899278,"threshold_uncertainty_score":0.999846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03852164958197837,"score_gpt":0.302805734406312,"score_spread":0.2642840848243336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}