{"id":"W4387310221","doi":"10.1016/j.nmd.2023.07.326","title":"P263 Targeting the innate immune system to block acute inflammatory responses and increase AAV viral transduction of skeletal muscle in mdx mice","year":2023,"lang":"en","type":"article","venue":"Neuromuscular Disorders","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"AGADA Biosciences","funders":"","keywords":"Innate immune system; Skeletal muscle; Biology; Immune system; Immunology; Complement system; Signal transduction; Internal medicine; Endocrinology; Pharmacology; Cell biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003304096,0.0007497897,0.0005149487,0.00053788,0.0003818,0.0004645603,0.000385615,0.0009288914,0.003095762],"category_scores_gemma":[0.0001463134,0.0002786426,0.0004970491,0.0002311648,0.0007842638,0.0004143653,0.0002493861,0.001862572,0.0007090782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000471626,"about_ca_system_score_gemma":0.0005479217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001013733,"about_ca_topic_score_gemma":0.002147507,"domain_scores_codex":[0.9996232,0.00005080822,0.00003574252,0.00008094854,0.00009971636,0.0001095833],"domain_scores_gemma":[0.9998011,0.00002818164,0.00006396456,0.00001341769,0.00001925696,0.00007397162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001388795,0.00008599155,0.00003665315,0.00003569919,0.00000446379,0.00003745903,0.00001409296,0.00005942072,0.9987466,0.0002231372,0.00005556645,0.0005620741],"study_design_scores_gemma":[0.0001079893,0.0009276495,0.001315153,0.0000152035,0.00002283798,0.0002433625,0.00003200708,0.0009291724,0.9940163,0.00009636513,0.002287695,0.000006313685],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821765,0.00142382,0.01097514,0.0006290714,0.0001487477,0.0002013407,0.001055304,0.0003920946,0.002997941],"genre_scores_gemma":[0.9719568,0.001184379,0.01298639,0.0002286305,0.00005575248,0.0003292972,0.0008442657,0.0001640444,0.01225053],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003095762,"threshold_uncertainty_score":0.01035643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005992220225275438,"score_gpt":0.248933716913785,"score_spread":0.2429414966885096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}