{"id":"W4387310221","doi":"10.1016/j.nmd.2023.07.326","title":"P263 Targeting the innate immune system to block acute inflammatory responses and increase AAV viral transduction of skeletal muscle in mdx mice","year":2023,"lang":"en","type":"article","venue":"Neuromuscular Disorders","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"AGADA Biosciences","funders":"","keywords":"Innate immune system; Skeletal muscle; Biology; Immune system; Immunology; Complement system; Signal transduction; Internal medicine; Endocrinology; Pharmacology; Cell biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008139437,0.0001780546,0.0001746185,0.000187978,0.0001182547,0.0000213389,0.0002686705,0.00009942992,0.000003798027],"category_scores_gemma":[0.0001720264,0.0001593637,0.000116599,0.0004144425,0.0001274385,0.000007530441,0.000149423,0.0001676331,0.000007531013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001353266,"about_ca_system_score_gemma":0.00008865024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001305369,"about_ca_topic_score_gemma":0.0002660769,"domain_scores_codex":[0.9981771,0.0005406682,0.0003046236,0.0003951509,0.0002465266,0.0003359765],"domain_scores_gemma":[0.9993668,0.00003598223,0.0000657687,0.0003925744,0.00005067106,0.00008820659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009613868,0.00003045,0.0005345095,0.00007242434,0.00005887144,0.00001213487,0.0002806015,0.001236829,0.9943774,0.000006090994,0.0000620194,0.002367322],"study_design_scores_gemma":[0.003353051,0.003179336,0.1145617,0.00009831494,0.00008582136,0.00002850186,0.002044644,0.001188085,0.8636671,0.00003521099,0.01108074,0.0006774894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975842,0.001124526,0.00001385066,0.0005770769,0.00009013456,0.0005270537,0.00002226857,0.00003091021,0.00002997538],"genre_scores_gemma":[0.9988878,0.0007262647,0.00002038715,0.00008238546,0.00004954252,0.00007484578,0.00004478934,0.00004511833,0.00006886124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1307102,"threshold_uncertainty_score":0.6498661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005992220225275438,"score_gpt":0.248933716913785,"score_spread":0.2429414966885096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}