{"id":"W4387316965","doi":"10.1039/d3cc04209j","title":"From a binding module to essential catalytic activity: how nature stumbled on a good thing","year":2023,"lang":"en","type":"review","venue":"Chemical Communications","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; PROTEO; Centre in Green Chemistry and Catalysis","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Metabolite; Imine; Chemistry; Catalysis; Combinatorial chemistry; Amino acid; Domain (mathematical analysis); Stereochemistry; Binding domain; Biochemistry; Binding site","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008012769,0.0007094415,0.0008673102,0.001074257,0.0004347683,0.001519704,0.0009292061,0.001844964,0.00205045],"category_scores_gemma":[0.001007963,0.0003546571,0.0003339273,0.001058756,0.002063511,0.003631586,0.0009312441,0.004021848,0.002133616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001404988,"about_ca_system_score_gemma":0.001228277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001418136,"about_ca_topic_score_gemma":0.001761437,"domain_scores_codex":[0.9997212,0.00006108399,0.00003417917,0.00005622653,0.00009317482,0.00003407997],"domain_scores_gemma":[0.9997073,0.000150522,0.00002618353,0.0000176585,0.00006227607,0.00003593311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001443536,0.00004912817,0.0002107512,0.007992695,0.00007000357,0.0004045502,0.0002487519,0.0005260871,0.003854712,0.07560305,0.07787809,0.8330178],"study_design_scores_gemma":[0.000007546207,0.00003062905,0.0001149861,0.0006818067,0.0000156952,0.0003362801,0.00004207744,0.00004675706,0.0003323253,0.007863557,0.9905195,0.000008839227],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002328281,0.991927,0.0005348057,0.003162456,0.001540366,0.000004421951,0.00001377713,0.00001771933,0.002566614],"genre_scores_gemma":[0.002908092,0.9875964,0.0007864712,0.003627059,0.001155247,0.0000132526,0.00003612168,0.00001271194,0.003864627],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00205045,"threshold_uncertainty_score":0.01019394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06118111199308442,"score_gpt":0.3568286085452259,"score_spread":0.2956474965521415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}