{"id":"W4387325932","doi":"10.1007/s10555-023-10145-8","title":"Sam68 is a druggable vulnerability point in cancer stem cells","year":2023,"lang":"en","type":"review","venue":"Cancer and Metastasis Reviews","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Ontario Ministry of Research, Innovation and Science; Canadian Institutes of Health Research; Government of Ontario; Cancer Research Society","keywords":"Druggability; Wnt signaling pathway; Biology; Carcinogenesis; Cancer stem cell; Chromatin; Cancer research; Stem cell; Cell biology; Cell cycle; Cancer cell; Transcription factor; Cancer; Computational biology; Signal transduction; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001535603,0.0005213327,0.002223181,0.0001428616,0.00008637064,0.00006056056,0.0003599756,0.0002615032,0.0001916441],"category_scores_gemma":[0.00005358293,0.0003715107,0.0006193168,0.0005062887,0.0001052763,0.00000748834,0.0002799535,0.0004124978,0.00006816545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001457289,"about_ca_system_score_gemma":0.0005144402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007168099,"about_ca_topic_score_gemma":0.0007737577,"domain_scores_codex":[0.9967446,0.0005179964,0.0009535913,0.0009906489,0.0001961106,0.0005970717],"domain_scores_gemma":[0.9986094,0.00004206177,0.0003122171,0.0007269132,0.00006399362,0.0002454777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000007642606,0.00002248467,0.0000119322,0.02056306,0.0001500085,0.000004390914,0.00002117457,9.231891e-7,0.000305785,0.00000302984,0.03064434,0.9482652],"study_design_scores_gemma":[0.000194295,0.00004558372,0.000001577043,0.006847733,0.0003091982,0.000002876049,0.00001623347,0.000003384097,0.0006289533,0.000006038235,0.9915722,0.0003719507],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002255086,0.9968997,0.00001584867,0.00008281221,0.00023356,0.001788766,0.0006387657,0.00001056623,0.0001045266],"genre_scores_gemma":[0.000002303254,0.986893,0.0000671459,0.0003074161,0.0002538974,0.002314941,0.00008864103,0.00007145824,0.0100012],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9609278,"threshold_uncertainty_score":0.9998737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1524305467355236,"score_gpt":0.4328963238707279,"score_spread":0.2804657771352042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}