{"id":"W4387326085","doi":"10.1007/s40263-023-01032-5","title":"Dextromethorphan-Bupropion for the Treatment of Depression: A Systematic Review of Efficacy and Safety in Clinical Trials","year":2023,"lang":"en","type":"review","venue":"CNS Drugs","topic":"Treatment of Major Depression","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; University of Toronto; McMaster University; Brain and Cognition Discovery Foundation; University Health Network","funders":"National Institute of Mental Health; National Institute on Aging","keywords":"Dextromethorphan; Bupropion; Medicine; Major depressive disorder; Internal medicine; Placebo; Adverse effect; Depression (economics); Randomized controlled trial; Meta-analysis; Rating scale; Hamilton Rating Scale for Depression; Psychiatry; Psychology; Smoking cessation; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004759121,0.001255758,0.008504972,0.003452625,0.0003961292,0.001668809,0.001611278,0.001350905,0.004387233],"category_scores_gemma":[0.01521979,0.0006490917,0.007045005,0.004346511,0.0007038949,0.001241044,0.001087383,0.001414728,0.0002437557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001777509,"about_ca_system_score_gemma":0.00346254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005700253,"about_ca_topic_score_gemma":0.02167073,"domain_scores_codex":[0.9975287,0.0008202516,0.0009136163,0.0002350573,0.0004220224,0.0000802724],"domain_scores_gemma":[0.9903837,0.007176129,0.001727305,0.0001092818,0.0004588142,0.0001447296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.001310274,0.00003314477,0.000460056,0.895605,0.03076416,0.00006797144,0.0000776681,0.0001723136,0.0003126549,0.000193408,0.001525095,0.0694782],"study_design_scores_gemma":[0.004096788,0.001044201,0.008570252,0.5377598,0.4145606,0.0005472578,0.0002678154,0.0002976547,0.000522614,0.000754789,0.03147287,0.0001053201],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005673065,0.9989024,0.00007382307,0.00007318063,0.00005299567,0.00009269515,0.0001261925,0.000005149448,0.0001061987],"genre_scores_gemma":[0.009599049,0.9893567,0.0004197371,0.0002945524,0.00004515208,0.000104325,0.00009991245,0.000003485681,0.0000770985],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.008504972,"threshold_uncertainty_score":0.0251689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2922463324314019,"score_gpt":0.533897522969662,"score_spread":0.2416511905382601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}