{"id":"W4387326961","doi":"10.1128/mbio.01807-23","title":"The Adr1 transcription factor directs regulation of the ergosterol pathway and azole resistance in <i>Candida albicans</i>","year":2023,"lang":"en","type":"article","venue":"mBio","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Concordia University; Université Laval; Montreal Heart Institute","funders":"Fonds de recherche du Québec; Concordia University; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Candida albicans; Transcription factor; Ergosterol; Corpus albicans; Biology; Zinc finger transcription factor; Biochemistry; Saccharomyces cerevisiae; Gene; Zinc finger; Microbiology; Cell biology; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007803732,0.0004755552,0.0001866024,0.000324374,0.0002608643,0.0004115834,0.0003308882,0.000226728,0.001994711],"category_scores_gemma":[0.000105866,0.0001534261,0.0002977761,0.0001358296,0.0001947535,0.0001030157,0.0002919011,0.0005645547,0.0008083501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007373895,"about_ca_system_score_gemma":0.0002277154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002349071,"about_ca_topic_score_gemma":0.002509419,"domain_scores_codex":[0.9997988,0.00001701587,0.00001333229,0.00007165116,0.00005459267,0.00004453642],"domain_scores_gemma":[0.9999143,0.000009740957,0.00001804347,0.0000117358,0.00001823328,0.00002794465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005678316,0.000009955566,0.0001749184,0.00001524416,0.000001711907,0.00003284104,0.00000504782,0.00003005464,0.9988507,0.00005275805,0.00007226921,0.0006977907],"study_design_scores_gemma":[0.00001222514,0.00005630165,0.01041737,0.000009114617,0.00001172001,0.0002264326,0.00003001346,0.001532637,0.9842032,0.00005188612,0.00344087,0.000008181836],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871238,0.002105648,0.003499277,0.0002110635,0.00009254739,0.00004212981,0.002473578,0.0003919051,0.004060059],"genre_scores_gemma":[0.9885014,0.0004453115,0.00217782,0.0001125809,0.00001934942,0.00003178849,0.002864142,0.00008296403,0.005764626],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002349071,"threshold_uncertainty_score":0.006672919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01344209510559718,"score_gpt":0.2388292469842727,"score_spread":0.2253871518786755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}