{"id":"W4387328184","doi":"10.1038/s41591-023-02502-5","title":"Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine","year":2023,"lang":"en","type":"review","venue":"Nature Medicine","topic":"Diabetes Management and Research","field":"Medicine","cited_by":201,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Population Health Research Institute; University of Manitoba; Université de Sherbrooke; McMaster University; Centre Hospitalier Universitaire Sainte-Justine; Impact; University of Calgary","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; NIHR Imperial Biomedical Research Centre; National Health and Medical Research Council; Center for Duchenne Muscular Dystrophy, University of California, Los Angeles; Medical Research Council; Merck Sharp and Dohme; Steno Diabetes Center Aarhus; National Institutes of Health; American Heart Association; Novo Nordisk Fonden; Pfizer; Diabetesforbundet; Horizon 2020 Framework Programme; Vetenskapsrådet; National Health Research Institutes; Novo Nordisk; Hjärt-Lungfonden; Innovation and Technology Commission; Australian Government; Norges Forskningsråd; Lunds Universitet; Albert-Ludwigs-Universität Freiburg; Novo Nordisk Foundation Center for Basic Metabolic Research; European Association for the Study of Diabetes; Pediatric Endocrine Society; Academy of Finland; Stiftelsen för Strategisk Forskning; Ministero della Salute; Leona M. and Harry B. Helmsley Charitable Trust; Croucher Foundation; Moonshot Research and Development Program; Canadian Institutes of Health Research; Diabetes UK; National Institute for Health and Care Research; John Templeton Foundation; British Heart Foundation; Boettcher Foundation; Diabetes Research Connection; Sun Pharma; Trond Mohn stiftelse; Bigfoot Biomedical; Dexcom; Insulet Corporation; Eli Lilly and Company; Immune Tolerance Network; MannKind Corporation; Doris Duke Charitable Foundation; Hong Kong Government; Wellcome Trust; Research England; AstraZeneca; European Commission; Steno Diabetes Center Copenhagen; Helsingin Yliopisto; KU Leuven; Hamilton Health Sciences; U.S. Department of Veterans Affairs; Daiichi Sankyo Europe; Yale University; Chinese University of Hong Kong; Sanofi; American Diabetes Association","keywords":"Precision medicine; Medicine; MEDLINE; Evidence-based medicine; Intensive care medicine; Common cause and special cause; Alternative medicine; Pathology; Political science; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02525534,0.001608971,0.004679901,0.007261671,0.0007342173,0.004660701,0.00329264,0.006219656,0.01024516],"category_scores_gemma":[0.02828952,0.0006517687,0.003752962,0.006096715,0.001448666,0.003898028,0.004570604,0.006822824,0.003241343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004722272,"about_ca_system_score_gemma":0.03134527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00601719,"about_ca_topic_score_gemma":0.007694894,"domain_scores_codex":[0.9934175,0.002096483,0.001227953,0.0006029378,0.002099996,0.0005551701],"domain_scores_gemma":[0.9642405,0.02219389,0.002287737,0.0007026825,0.009010472,0.001564671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004878506,0.0001145535,0.0003758307,0.1158182,0.0008235558,0.0002404033,0.0002714341,0.0004174931,0.0008624702,0.02041213,0.2651476,0.5950285],"study_design_scores_gemma":[0.000128193,0.00008957636,0.0009657637,0.07216792,0.001435011,0.000253257,0.0001496638,0.00008760729,0.0002821438,0.00438492,0.9200143,0.00004163765],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001073481,0.9709499,0.0007008886,0.01928347,0.006069489,0.00006124135,0.0005090631,0.00003188013,0.002286706],"genre_scores_gemma":[0.001448683,0.9800369,0.002027495,0.0124465,0.001852939,0.0001531666,0.0007101929,0.00001885718,0.001305258],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.02525534,"threshold_uncertainty_score":0.1335646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3213265269663893,"score_gpt":0.5042445191692628,"score_spread":0.1829179922028735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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