{"id":"W4387330509","doi":"10.1038/s41467-023-41912-4","title":"Alternative splicing in lung influences COVID-19 severity and respiratory diseases","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill Genome Centre; McGill University; Jewish General Hospital","funders":"Medical Research Council; Fonds de Recherche du Québec - Santé; National Institutes of Health; Fondation de l'Hôpital général juif; Ministry of Education, Culture, Sports, Science and Technology; European Commission; King's College London; Jewish General Hospital; National Institute for Health and Care Research; Canada Foundation for Innovation; Canadian Institutes of Health Research; Wellcome; Compute Canada; Japan Society for the Promotion of Science; Cancer Research UK; Public Health Agency; Government of Canada; McGill University; Public Health Agency of Canada; Wellcome Trust","keywords":"RNA splicing; Alternative splicing; Biology; Genetics; Computational biology; Immunology; Gene; Gene isoform; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005396514,0.0002384223,0.0002620029,0.0006901309,0.000199553,0.0003709546,0.0001497556,0.0002111605,0.002128821],"category_scores_gemma":[0.0007913159,0.0001212274,0.0003227367,0.000389992,0.000317583,0.0001418768,0.0003150354,0.0003179125,0.000139429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001658983,"about_ca_system_score_gemma":0.0001250344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000376721,"about_ca_topic_score_gemma":0.0005709562,"domain_scores_codex":[0.9994166,0.000183599,0.00005031232,0.0001652412,0.0001232605,0.00006101275],"domain_scores_gemma":[0.9992684,0.000224196,0.0002910632,0.00007184826,0.00004199538,0.0001025421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001248995,0.00005955586,0.305263,0.00004173683,0.0001117062,0.0004299135,0.00006239978,0.0001999777,0.6863035,0.000287369,0.00006267556,0.005929333],"study_design_scores_gemma":[0.00001608211,0.0003831452,0.9586986,0.000005667804,0.00007037747,0.001572468,0.00008285441,0.001337683,0.03703233,0.0003045956,0.0004865094,0.000009708039],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978989,0.0001309718,0.001366327,0.00002269537,0.000004378177,0.000009376523,0.000237394,0.00001662169,0.0003133024],"genre_scores_gemma":[0.9989004,0.00004199361,0.0006830965,0.0000119495,0.000002318164,0.000005854664,0.0001845861,0.000009378927,0.0001604169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002128821,"threshold_uncertainty_score":0.007121563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03212864506053222,"score_gpt":0.3719458894035007,"score_spread":0.3398172443429684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}