{"id":"W4387333855","doi":"10.3390/biology12101307","title":"Microglia and Astrocytes in Amyotrophic Lateral Sclerosis: Disease-Associated States, Pathological Roles, and Therapeutic Potential","year":2023,"lang":"en","type":"review","venue":"Biology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; University of Toronto; Fondation Brain Canada","keywords":"Microglia; Amyotrophic lateral sclerosis; Biology; Pathogenesis; Neuroscience; Neuroprotection; Disease; Astrocyte; Multiple sclerosis; Neuroinflammation; Pathological; Gliosis; Central nervous system; Immunology; Pathology; Inflammation; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000385261,0.00069701,0.001119265,0.002297282,0.0002622871,0.000951902,0.0005648281,0.0009723475,0.003308609],"category_scores_gemma":[0.0004743582,0.0001908594,0.0003600945,0.002028034,0.0003634347,0.001117013,0.00063564,0.001330693,0.001541323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004498979,"about_ca_system_score_gemma":0.0009772899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008061235,"about_ca_topic_score_gemma":0.001644843,"domain_scores_codex":[0.9998723,0.00002252145,0.00002219531,0.00002109797,0.00004868793,0.00001323963],"domain_scores_gemma":[0.9998254,0.00008077888,0.00002788751,0.000004697928,0.00004248313,0.00001883122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009873704,0.00007394957,0.000151097,0.02350606,0.00007483739,0.0002437925,0.0001059603,0.0003238298,0.002604828,0.004189538,0.02172913,0.9468982],"study_design_scores_gemma":[0.00001771756,0.0001278819,0.0009150546,0.006854044,0.0001414138,0.001818281,0.0001042864,0.00007195533,0.0004650637,0.002873272,0.9865924,0.00001873987],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007798531,0.9991211,0.00004927773,0.000117446,0.00009429925,0.00000234316,0.000009483961,0.000003468062,0.0005245712],"genre_scores_gemma":[0.0004099649,0.9989905,0.00009117874,0.00009315335,0.00008478377,0.000003924113,0.0000162896,6.828425e-7,0.0003094788],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003308609,"threshold_uncertainty_score":0.01106834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09129994269364901,"score_gpt":0.3494048101144893,"score_spread":0.2581048674208403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}