{"id":"W4387337690","doi":"10.1016/j.cjca.2023.06.321","title":"INTEGRATIVE PROTEOGENOMICS ANALYSIS IDENTIFIES COL6A3-DERIVED ENDOTROPHIN AS AN ACTIONABLE MEDIATOR OF THE EFFECT OF OBESITY ON CORONARY ARTERY DISEASE","year":2023,"lang":"en","type":"article","venue":"Canadian Journal of Cardiology","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Medicine; Mendelian randomization; Mediator; Disease; Coronary artery disease; Obesity; Proteome; Bioinformatics; Colocalization; Mediation; Diabetes mellitus; Internal medicine; Type 2 diabetes; Computational biology; Cardiology; Endocrinology; Gene; Genetics; Neuroscience; Biology; Genotype","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002226878,0.0004293607,0.0003033194,0.0005152706,0.0002313458,0.0004062614,0.0001929906,0.0002391064,0.001276728],"category_scores_gemma":[0.0001383923,0.0001226629,0.0005106472,0.0003004736,0.0001752162,0.0001534288,0.0003135432,0.0004892717,0.0002284779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002187733,"about_ca_system_score_gemma":0.0002380895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00115071,"about_ca_topic_score_gemma":0.002065776,"domain_scores_codex":[0.9998829,0.0000120071,0.00000449123,0.00003133443,0.00003943362,0.00002971557],"domain_scores_gemma":[0.9999245,0.00001078918,0.00002830345,0.000006523578,0.00001097727,0.00001892581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003847242,0.00003347728,0.00502409,0.00004413547,0.00006921553,0.0001748209,0.00001605188,0.0002606051,0.9906447,0.0001417684,0.0001554243,0.003050931],"study_design_scores_gemma":[0.00007827658,0.0004407489,0.5951988,0.00003064454,0.0004215315,0.001876957,0.0002266536,0.01846,0.3771859,0.0009047223,0.005128001,0.00004778735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912536,0.001101041,0.00495321,0.000173275,0.00004066404,0.00001979839,0.001461555,0.00006468024,0.0009321867],"genre_scores_gemma":[0.9918595,0.000484875,0.004523497,0.0001147382,0.0000154329,0.0000145979,0.00202786,0.00002807332,0.0009314076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001276728,"threshold_uncertainty_score":0.00427109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0129663389105905,"score_gpt":0.2764512343487829,"score_spread":0.2634848954381924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}