{"id":"W4387337782","doi":"10.1016/j.cjca.2023.06.180","title":"KNOCK-IN OF MCARDINAL AT THE MOUSE GCK LOCUS AS A TOOL TO EXPLORE PANCREATIC BETA CELL HETEROGENEITY","year":2023,"lang":"en","type":"article","venue":"Canadian Journal of Cardiology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Glucokinase; Glycolysis; Beta cell; Transcriptome; Islet; Medicine; Endocrinology; Population; Cell; Locus (genetics); Insulin; Internal medicine; Cell biology; Gene; Metabolism; Biochemistry; Gene expression; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005688285,0.0005798581,0.0005408865,0.001543892,0.0005879502,0.001043424,0.0006662894,0.000923533,0.004404332],"category_scores_gemma":[0.0003281313,0.0004836404,0.0004796939,0.000587293,0.0010072,0.0006528607,0.0007097749,0.002355166,0.0008307991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005924453,"about_ca_system_score_gemma":0.0004142809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001261597,"about_ca_topic_score_gemma":0.00327188,"domain_scores_codex":[0.9994554,0.00005699919,0.00005835177,0.0001801133,0.0001185208,0.0001305149],"domain_scores_gemma":[0.9992672,0.0001834144,0.0002062001,0.0001055259,0.00003278166,0.0002048819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001596924,0.00004063246,0.0001746862,0.00001890645,0.000007169594,0.0001130473,0.00004230611,0.00005542593,0.9982027,0.0005022835,0.00005321422,0.000629911],"study_design_scores_gemma":[0.0001307008,0.0002153228,0.003094959,0.00001954938,0.00005957855,0.0007908434,0.0001398303,0.00145025,0.9876348,0.0002941006,0.006152725,0.00001735305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9706638,0.002010375,0.01875619,0.0007200826,0.0003645128,0.0001695596,0.001734248,0.0005615207,0.005019662],"genre_scores_gemma":[0.9754972,0.0009681489,0.01325801,0.0003579276,0.00006021429,0.0001828729,0.0008308378,0.0005031438,0.008341614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004404332,"threshold_uncertainty_score":0.01473397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03672600408333233,"score_gpt":0.2675032310501034,"score_spread":0.2307772269667711,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}