{"id":"W4387338036","doi":"10.1016/j.cjca.2023.06.366","title":"THE DIRECT AMPK-β1 SELECTIVE ACTIVATOR PF-06409577 TARGETS MACROPHAGES TO REDUCE ATHEROSCLEROSIS IN MICE","year":2023,"lang":"en","type":"article","venue":"Canadian Journal of Cardiology","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Public Health","funders":"","keywords":"Medicine; AMPK; Metformin; Dyslipidemia; Inflammation; Activator (genetics); Disease; Canagliflozin; Bioavailability; Pharmacology; Diabetes mellitus; Internal medicine; Endocrinology; Kinase; Protein kinase A; Type 2 diabetes; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003603847,0.0008467064,0.0008716837,0.0008847513,0.0004461637,0.0006064632,0.0007018396,0.0009514146,0.003414916],"category_scores_gemma":[0.000195309,0.0005644571,0.0007183169,0.0004246981,0.0006687026,0.0004733532,0.0003285937,0.002754594,0.001147154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005296249,"about_ca_system_score_gemma":0.0008548577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001342257,"about_ca_topic_score_gemma":0.002627906,"domain_scores_codex":[0.99961,0.0000331447,0.00002897833,0.00007449574,0.00009849235,0.0001548839],"domain_scores_gemma":[0.9997913,0.0000140325,0.00005670394,0.00002192257,0.00001959949,0.0000964491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005491204,0.0009354832,0.0003462347,0.0002235971,0.00007686577,0.0001820972,0.00005038885,0.0003854686,0.9798878,0.0008798563,0.001140195,0.01040082],"study_design_scores_gemma":[0.001203303,0.003515233,0.003012694,0.00004582964,0.0001753594,0.0003181663,0.0001167069,0.001115439,0.9822384,0.0004707352,0.007762345,0.00002564686],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.977546,0.004335796,0.0049842,0.002254966,0.0006420786,0.0001225937,0.001864428,0.0009080254,0.007341953],"genre_scores_gemma":[0.9787701,0.003951471,0.003815304,0.0007297213,0.0001410669,0.0002398299,0.001226705,0.00016998,0.01095575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003414916,"threshold_uncertainty_score":0.01142406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01106603952731578,"score_gpt":0.2431672988018453,"score_spread":0.2321012592745295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}