{"id":"W4387338045","doi":"10.1016/j.cjca.2023.06.178","title":"IMPACT OF MFN2 DELETION ON INSULIN SECRETION AND TRANSIENT MITOCHONDRIAL PERMEABILITY TRANSITION PORE OPENING IN HUMAN ENDOCBH3 BETA CELLS","year":2023,"lang":"en","type":"article","venue":"Canadian Journal of Cardiology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"MFN2; MFN1; Mitochondrial permeability transition pore; Mitochondrion; mitochondrial fusion; Medicine; Beta cell; Cell biology; Endocrinology; Insulin; Internal medicine; Biology; Mitochondrial DNA; Programmed cell death; Gene; Apoptosis; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000256066,0.0003303719,0.0002982449,0.0001481912,0.00030264,0.0005531969,0.0002687026,0.0005839579,0.003134681],"category_scores_gemma":[0.0001945317,0.0001550035,0.0003789501,0.0001858772,0.0004473487,0.0003253744,0.0002825877,0.0008523409,0.0005058135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002605377,"about_ca_system_score_gemma":0.0003297903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001550021,"about_ca_topic_score_gemma":0.001426845,"domain_scores_codex":[0.9997486,0.00003556088,0.00003382207,0.00006355218,0.00005105368,0.00006742557],"domain_scores_gemma":[0.9998446,0.00003831521,0.00002793689,0.00002016399,0.00001266857,0.00005640244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001196689,0.0001208867,0.0004248825,0.00004732379,0.00001643008,0.0003359933,0.00005851984,0.0001142078,0.9964744,0.000141773,0.0001475193,0.0009213367],"study_design_scores_gemma":[0.0002671769,0.001167919,0.01785919,0.00002538032,0.00009070355,0.001033814,0.0003522988,0.001550756,0.9702902,0.0001325027,0.007205716,0.00002445438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967985,0.0005024248,0.0005008267,0.0001721173,0.00008822305,0.00001624902,0.000755608,0.00003083787,0.001135308],"genre_scores_gemma":[0.9961089,0.0002667785,0.0005232922,0.0001365899,0.00001813402,0.00004260692,0.0008792742,0.00002659366,0.001997642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003134681,"threshold_uncertainty_score":0.01048648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01980872207850646,"score_gpt":0.2706331993997687,"score_spread":0.2508244773212622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}