{"id":"W4387338049","doi":"10.1016/j.cjca.2023.06.280","title":"COMBINATION OF EICOSAPENTAENOIC ACID (EPA) AND A STATIN INCREASED EXPRESSION OF DETOXIFICATION PROTEINS IN VASCULAR ENDOTHELIAL CELLS DURING INFLAMMATION","year":2023,"lang":"en","type":"article","venue":"Canadian Journal of Cardiology","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Eicosapentaenoic acid; Rosuvastatin; Reactive oxygen species; Medicine; Detoxification (alternative medicine); Inflammation; Angiotensin II; Endothelial dysfunction; Oxidative stress; Angiotensin-converting enzyme 2; Heme oxygenase; Statin; Pharmacology; Internal medicine; Biochemistry; Endocrinology; Enzyme; Polyunsaturated fatty acid; Heme; Fatty acid; Chemistry; Receptor","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000266158,0.0002838298,0.0009035367,0.0002285289,0.0003511643,0.0004563418,0.0001461616,0.0003810737,0.00220464],"category_scores_gemma":[0.0002562787,0.0002415437,0.0006602032,0.0003296269,0.000321107,0.0004016843,0.0002846693,0.001015521,0.000393227],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003310643,"about_ca_system_score_gemma":0.0007248938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001821509,"about_ca_topic_score_gemma":0.003792821,"domain_scores_codex":[0.9996073,0.0000554655,0.00004454721,0.00006849154,0.00006548429,0.0001586612],"domain_scores_gemma":[0.9998094,0.00002430549,0.0000228896,0.00002262548,0.00004297273,0.00007768298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007126514,0.0001960703,0.0008799118,0.0001154402,0.00004063653,0.0001361154,0.00006367151,0.00005130402,0.9893092,0.00006580711,0.0001452049,0.001870071],"study_design_scores_gemma":[0.0004032633,0.004016928,0.03982921,0.00002424449,0.000305698,0.0003194736,0.0005254151,0.001200757,0.9496711,0.0001241868,0.00355181,0.00002794294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953079,0.001766434,0.001097075,0.0002409271,0.0002560384,0.00003440525,0.0003701612,0.0000352414,0.0008919162],"genre_scores_gemma":[0.9942157,0.0008338253,0.0009707025,0.0001406323,0.00004861342,0.00007949939,0.0003532931,0.000009778988,0.003348017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00220464,"threshold_uncertainty_score":0.00737524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008470218150984027,"score_gpt":0.2231103700100587,"score_spread":0.2146401518590746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}