{"id":"W4387338440","doi":"10.1016/j.cjca.2023.06.026","title":"THE ROLE OF MICRORNAS IN HYPERTROPHIC CARDIOMYOPATHY: INSIGHTS FROM PATIENT-DERIVED INDUCED PLURIPOTENT STEM CELL CARDIOMYOCYTES AND MYOCARDIAL TISSUE","year":2023,"lang":"en","type":"article","venue":"Canadian Journal of Cardiology","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Public Health","funders":"","keywords":"Hypertrophic cardiomyopathy; MYH7; Induced pluripotent stem cell; Medicine; microRNA; Myosin; Muscle hypertrophy; Myocyte; Disease; MYH6; Cardiology; Internal medicine; Bioinformatics; Cell biology; Gene; Myosin light-chain kinase; Genetics; Biology; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006997442,0.0002438198,0.0003075712,0.0004538277,0.0002385915,0.0008265746,0.0002664385,0.000570101,0.001081826],"category_scores_gemma":[0.0005514767,0.0001967161,0.000255184,0.0002153741,0.0004384588,0.0003801999,0.0004105281,0.0007516895,0.000203108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000289004,"about_ca_system_score_gemma":0.0004878732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005227246,"about_ca_topic_score_gemma":0.00121503,"domain_scores_codex":[0.9997308,0.00006543387,0.00003030407,0.00004279407,0.00009568324,0.00003498871],"domain_scores_gemma":[0.9998096,0.00007206887,0.00003698762,0.00001629376,0.00003889044,0.00002633859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004607513,0.00008174087,0.0128196,0.0004547497,0.00007819609,0.002976772,0.0005561019,0.0003150518,0.9291386,0.008231773,0.0009678678,0.04391881],"study_design_scores_gemma":[0.0001287548,0.001819372,0.1943747,0.0003189816,0.0004594593,0.01862353,0.002069444,0.003634667,0.7013215,0.005486893,0.07167265,0.0000900541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8945055,0.06434899,0.02041372,0.003377965,0.0005031808,0.00012954,0.0008302829,0.0001449374,0.01574582],"genre_scores_gemma":[0.9735768,0.01649015,0.005728265,0.001026163,0.0001441581,0.00005999565,0.0004363526,0.00003068489,0.002507441],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001081826,"threshold_uncertainty_score":0.003700614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01130131513444474,"score_gpt":0.2067767395741094,"score_spread":0.1954754244396647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}