{"id":"W4387340250","doi":"10.1016/j.molmet.2023.101815","title":"Loss of carnitine palmitoyltransferase 1a reduces docosahexaenoic acid-containing phospholipids and drives sexually dimorphic liver disease in mice","year":2023,"lang":"en","type":"article","venue":"Molecular Metabolism","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Drug Abuse; National Heart, Lung, and Blood Institute; National Institutes of Health, Pakistan; American Heart Association; Clinical and Translational Science Collaborative of Cleveland, School of Medicine, Case Western Reserve University; National Cancer Institute; National Institutes of Health; American Cancer Society; KU Leuven; National Institute of General Medical Sciences; Case Comprehensive Cancer Center, Case Western Reserve University; University of Alberta","keywords":"Docosahexaenoic acid; Sexual dimorphism; Endocrinology; Internal medicine; Carnitine; Disease; Biology; Medicine; Chemistry; Biochemistry; Fatty acid; Polyunsaturated fatty acid","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004390903,0.001010058,0.0005514814,0.001699487,0.0004288623,0.0006193282,0.0006164511,0.000873076,0.004948134],"category_scores_gemma":[0.000275324,0.0006818268,0.0006410021,0.0004888298,0.000886414,0.0003319792,0.0006294858,0.001349324,0.001018105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006316605,"about_ca_system_score_gemma":0.0004823902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009740122,"about_ca_topic_score_gemma":0.002527464,"domain_scores_codex":[0.9993466,0.00009783037,0.00007701463,0.0002246172,0.0001385765,0.0001154217],"domain_scores_gemma":[0.9989187,0.00008445932,0.0005210257,0.00007268458,0.00004650921,0.000356631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004727439,0.00009207516,0.0008957484,0.00004374727,0.00001894433,0.0001314541,0.00002892094,0.00004866497,0.9971378,0.0001060264,0.00007375185,0.0009502588],"study_design_scores_gemma":[0.0003586476,0.001419298,0.05051418,0.0000811134,0.0001703504,0.002242122,0.0002614804,0.001426672,0.9381025,0.0002303155,0.005155394,0.00003796665],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900771,0.001500171,0.003105395,0.0004212177,0.00006664034,0.00007955355,0.00302998,0.0003772404,0.001342658],"genre_scores_gemma":[0.9778609,0.001608196,0.005235364,0.0003608386,0.00003809244,0.0002763935,0.002300684,0.0003446188,0.01197491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004948134,"threshold_uncertainty_score":0.01655316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007169131612171845,"score_gpt":0.2316470791309826,"score_spread":0.2244779475188108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}