{"id":"W4387348799","doi":"10.1016/b978-0-323-95488-4.00002-4","title":"Uptake Transporters","year":2023,"lang":"en","type":"book-chapter","venue":"Elsevier eBooks","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Transporter; Solute carrier family; Efflux; Organic anion transporter 1; Organic cation transport proteins; Membrane transport protein; Biochemistry; Organic anion-transporting polypeptide; Xenobiotic; Chemistry; Biology; Cotransporter; Zwitterion; Sodium; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001948939,0.001896338,0.001285125,0.001431739,0.0009298344,0.003624243,0.00100715,0.002022669,0.1441211],"category_scores_gemma":[0.000257003,0.0006601885,0.000652987,0.002193375,0.0005516486,0.002769174,0.001610506,0.002396365,0.1758205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009827225,"about_ca_system_score_gemma":0.0008125578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001848294,"about_ca_topic_score_gemma":0.002381777,"domain_scores_codex":[0.999811,0.00001236107,0.000009132959,0.00004953767,0.00009471373,0.00002323445],"domain_scores_gemma":[0.9999207,0.00001556539,0.000006866185,0.00001422116,0.00003118488,0.00001133184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009897585,0.0001005989,0.0001273862,0.001200342,0.00002053374,0.0004561577,0.0002498046,0.0005468659,0.05702117,0.05988579,0.2349973,0.6452951],"study_design_scores_gemma":[0.000005545742,0.00001910214,0.0001168826,0.0001273859,0.000007898448,0.0003642377,0.00004386041,0.0002332533,0.005078638,0.005424676,0.9885702,0.000008416743],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.002201506,0.06306085,0.01779776,0.002600368,0.002029189,0.00009700959,0.001717442,0.002095477,0.9084003],"genre_scores_gemma":[0.003003274,0.01759218,0.002788075,0.0005330222,0.0001468016,0.00004922643,0.0009643399,0.0002005556,0.9747225],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.1441211,"threshold_uncertainty_score":0.482133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02187519222178523,"score_gpt":0.2402657851278032,"score_spread":0.218390592906018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}