{"id":"W4387357363","doi":"10.1128/mbio.01655-23","title":"The SET and ankyrin domains of the secreted <i>Legionella pneumophila</i> histone methyltransferase work together to modify host chromatin","year":2023,"lang":"en","type":"article","venue":"mBio","topic":"Legionella and Acanthamoeba research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; Agence Nationale de la Recherche; Canada Research Chairs; Canadian HIV Trials Network, Canadian Institutes of Health Research; Canadian Light Source","keywords":"Legionella pneumophila; Ankyrin repeat; Chromatin; Host (biology); Histone; Histone methyltransferase; Legionella; Microbiology; Biology; Cell biology; Genetics; Bacteria; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007438125,0.000348253,0.0002304843,0.0001002388,0.0001648806,0.0002466429,0.0002519916,0.0002639687,0.001151485],"category_scores_gemma":[0.0001193247,0.0001580385,0.0003367667,0.00008337399,0.000197289,0.0002160536,0.000249697,0.0004780115,0.0003736291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003317018,"about_ca_system_score_gemma":0.0001844352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004390884,"about_ca_topic_score_gemma":0.0004288602,"domain_scores_codex":[0.9999535,0.000004992667,0.000002864246,0.00001329349,0.00001431263,0.00001102349],"domain_scores_gemma":[0.9999083,0.00001139276,0.00003151311,0.000006138834,0.000007457845,0.0000352036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000100798,0.00002152724,0.001317306,0.00006450412,0.00002978429,0.0003221361,0.00003168844,0.0007107269,0.9956726,0.0001623899,0.000111251,0.001455358],"study_design_scores_gemma":[0.0001378956,0.0005424577,0.05059914,0.00003265121,0.00007335768,0.002440098,0.0001451397,0.01274796,0.9264284,0.0005787063,0.006232633,0.00004145931],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969442,0.0005300275,0.001657003,0.00006963994,0.00001615749,0.000007785588,0.0000982089,0.00007903741,0.0005978901],"genre_scores_gemma":[0.9957567,0.0001404504,0.002662606,0.00005678917,0.000006911979,0.000006866114,0.0003042523,0.00001585379,0.001049598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001151485,"threshold_uncertainty_score":0.003852069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01572974806506264,"score_gpt":0.280293057000581,"score_spread":0.2645633089355183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}