{"id":"W4387358894","doi":"10.1101/2023.10.04.23296543","title":"GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets","year":2023,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University of Toronto; Memorial University of Newfoundland; University Health Network; Nexus Clinical Research (Canada)","funders":"Norwegian Institute of Public Health; Faculty of Medicine and Health, University of Sydney; Medical Research Council; NIHR BioResource; Manchester Biomedical Research Centre; University of California, San Francisco; Multiple Sclerosis Society of Western Australia; National Institutes of Health; Heinz Nixdorf Stiftung; Versus Arthritis; St. Olavs Hospital Universitetssykehuset i Trondheim; Norges Forskningsråd; Krembil Foundation; Institute of Psychiatry, Psychology and Neuroscience, King’s College London; Deutsches Zentrum für Neurodegenerative Erkrankungen; Helse Midt-Norge; Deutsche Forschungsgemeinschaft; European Commission; King's College London; U.S. Department of Veterans Affairs; Helene Morgan Babcock and Alfred Babcock Memorial Scholarship Trust; University of Toronto; Eesti Teadusagentuur; European Federation of Pharmaceutical Industries and Associations; NIHR Cambridge Biomedical Research Centre; Maudsley Charity; Multiple Sclerosis Society; Pfizer; National Psoriasis Foundation; LEO Fondet; Stiftelsen Kristian Gerhard Jebsen; NIHR Maudsley Biomedical Research Centre; Norges Teknisk-Naturvitenskapelige Universitet; A. Alfred Taubman Medical Research Institute; Fakultet for medisin og helsevitenskap, Norges Teknisk-Naturvitenskapelige Universitet; Michael J. Fox Foundation for Parkinson's Research; European Regional Development Fund; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research","keywords":"Psoriasis; Genome-wide association study; Epigenetics; Biology; Disease; Transcriptome; Genetics; Genetic predisposition; Allele; Single-nucleotide polymorphism; Immunology; Medicine; Genotype; Gene; Gene expression; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006138892,0.001234459,0.002960549,0.002002989,0.0004940962,0.002659024,0.000945438,0.001038658,0.006066966],"category_scores_gemma":[0.009790434,0.0006243444,0.01090069,0.003872881,0.0004573477,0.0006864664,0.001085199,0.00165045,0.0005127325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003805743,"about_ca_system_score_gemma":0.0005250048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002138649,"about_ca_topic_score_gemma":0.002235917,"domain_scores_codex":[0.9950777,0.002281261,0.0004507212,0.001388984,0.0004758742,0.0003253865],"domain_scores_gemma":[0.9914442,0.005473092,0.0009946349,0.001418468,0.0003617215,0.0003077896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.01006249,0.00007341232,0.5161746,0.004984191,0.4089978,0.00103741,0.0001521498,0.005955986,0.0115973,0.001632954,0.006614867,0.03271692],"study_design_scores_gemma":[0.001335906,0.0007575518,0.5392458,0.0009340734,0.4193718,0.001788486,0.0003034387,0.01240665,0.004216646,0.008132082,0.01141466,0.00009270037],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6957103,0.2398261,0.03618177,0.004855559,0.001352871,0.000148157,0.01615631,0.001134361,0.004634632],"genre_scores_gemma":[0.9877911,0.006633378,0.002337809,0.0004453038,0.0002706473,0.0000530398,0.001877984,0.0001391046,0.0004516701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006138892,"threshold_uncertainty_score":0.03246593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09510250165322937,"score_gpt":0.3091345521932678,"score_spread":0.2140320505400384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}