{"id":"W4387360319","doi":"10.1101/2023.10.03.560698","title":"Alterations in DNA 5-hydroxymethylation Patterns in the Hippocampus of an Experimental Model of Refractory Epilepsy","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"National Institute of Neurological Disorders and Stroke; Yale University","keywords":"Epilepsy; Epileptogenesis; Epigenetics; DNA methylation; Hippocampus; Kainic acid; Biology; Temporal lobe; Intergenic region; Neuroscience; Gene; Gene expression; Genetics; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008316373,0.0004211714,0.0002713302,0.0005618886,0.0001461418,0.0001576203,0.0001793647,0.0002116203,0.001552837],"category_scores_gemma":[0.00008994518,0.0001689436,0.0002667216,0.0001734732,0.0002948745,0.0001797554,0.0001715266,0.000558993,0.0001925287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000266248,"about_ca_system_score_gemma":0.0001770003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001176299,"about_ca_topic_score_gemma":0.001900971,"domain_scores_codex":[0.9998881,0.00001051499,0.000009266011,0.00003590247,0.00002463151,0.00003152116],"domain_scores_gemma":[0.9998881,0.000007894009,0.00004210871,0.00001224812,0.00001719734,0.00003252749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004763236,0.00005052226,0.0003919565,0.00003187219,0.00001408161,0.00006164613,0.00002300461,0.00003231504,0.9980187,0.00003107715,0.00002864111,0.0008397746],"study_design_scores_gemma":[0.00006183356,0.001503727,0.01752788,0.000009671555,0.00006689583,0.0003682739,0.0001257175,0.0008436755,0.9781919,0.0000938108,0.001195911,0.00001070702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961295,0.001010521,0.001481,0.00006863837,0.00004519886,0.0000271524,0.0006635304,0.00005894333,0.0005153767],"genre_scores_gemma":[0.9959908,0.0005254144,0.0007094734,0.00004714509,0.000006478102,0.00007119749,0.0006532199,0.00001499223,0.001981328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001552837,"threshold_uncertainty_score":0.005194783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02526993719973248,"score_gpt":0.2685777560243298,"score_spread":0.2433078188245973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}