{"id":"W4387361013","doi":"10.1210/jendso/bvad114.1525","title":"OR27-03 Oral Infigratinib Treatment Is Well Tolerated And Significantly Increases Height Velocity In Children With Achondroplasia: Month 6 Results From The PROPEL 2 Dose-finding Study","year":2023,"lang":"en","type":"article","venue":"Journal of the Endocrine Society","topic":"Neonatal Health and Biochemistry","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Hospices Civils de Lyon; Ipsen; University of Alberta; Idorsia Pharmaceuticals; Amicus Therapeutics; Murdoch Children's Research Institute; NHS Greater Glasgow and Clyde; Université de Toulouse; Cincinnati Children's Hospital Medical Center; Sheffield Children's NHS Foundation Trust; Children’s Hospital of Wisconsin Research Institute; Sanofi; Vanderbilt University; Alexion Pharmaceuticals; University of California, San Francisco; Institut des maladies génétiques Imagine; Vanderbilt University Medical Center; Audentes Therapeutics; Amgen; Johns Hopkins University; Pfizer","keywords":"Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003516826,0.0002134524,0.0003963374,0.00002455772,0.00021726,0.00003729694,0.0001780475,0.00004808555,0.00001951546],"category_scores_gemma":[0.0001036312,0.00009037064,0.0001485161,0.0004426537,0.00009466143,0.00006173821,0.00008413204,0.0005179125,0.000003970682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001574146,"about_ca_system_score_gemma":0.0003257353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002185332,"about_ca_topic_score_gemma":0.0002887921,"domain_scores_codex":[0.9984205,0.0001216151,0.0005083518,0.0002312904,0.0004212389,0.0002969808],"domain_scores_gemma":[0.9989352,0.0001855925,0.000340197,0.0002762604,0.0001006579,0.0001620621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00238401,0.0009424232,0.9652256,0.0000315544,0.0006907753,0.0002192492,0.004284955,0.00001632912,0.001299078,4.661702e-7,0.02277973,0.002125816],"study_design_scores_gemma":[0.01398773,0.001480873,0.9681375,0.0002291071,0.000282273,0.0004910749,0.006234159,0.0001428195,0.007787371,0.000009861507,0.001086406,0.000130835],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942241,0.0003229023,2.290626e-7,0.00437237,0.00006089647,0.0007790609,0.0001455368,0.00001848831,0.00007646451],"genre_scores_gemma":[0.9978644,0.0004170122,0.0001648643,0.0004452623,0.0002678675,0.00001048665,0.00003411445,0.00001676415,0.0007792888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02169332,"threshold_uncertainty_score":0.3685208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02421671536513236,"score_gpt":0.2917548519157479,"score_spread":0.2675381365506155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}