{"id":"W4387361013","doi":"10.1210/jendso/bvad114.1525","title":"OR27-03 Oral Infigratinib Treatment Is Well Tolerated And Significantly Increases Height Velocity In Children With Achondroplasia: Month 6 Results From The PROPEL 2 Dose-finding Study","year":2023,"lang":"en","type":"article","venue":"Journal of the Endocrine Society","topic":"Neonatal Health and Biochemistry","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Hospices Civils de Lyon; Ipsen; University of Alberta; Idorsia Pharmaceuticals; Amicus Therapeutics; Murdoch Children's Research Institute; NHS Greater Glasgow and Clyde; Université de Toulouse; Cincinnati Children's Hospital Medical Center; Sheffield Children's NHS Foundation Trust; Children’s Hospital of Wisconsin Research Institute; Sanofi; Vanderbilt University; Alexion Pharmaceuticals; University of California, San Francisco; Institut des maladies génétiques Imagine; Vanderbilt University Medical Center; Audentes Therapeutics; Amgen; Johns Hopkins University; Pfizer","keywords":"Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001162733,0.000467703,0.001537278,0.0002339669,0.0001934858,0.0007086425,0.0004598493,0.0006732274,0.00321598],"category_scores_gemma":[0.001942054,0.0001400906,0.001370517,0.0004003822,0.000308648,0.0004943291,0.0002184807,0.00133721,0.000702477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006017195,"about_ca_system_score_gemma":0.0005788589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001216189,"about_ca_topic_score_gemma":0.003156258,"domain_scores_codex":[0.9991552,0.0002804999,0.00009668731,0.000120985,0.000241782,0.0001048722],"domain_scores_gemma":[0.9985673,0.000379541,0.0004578709,0.0001146428,0.0001429714,0.0003376016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1933754,0.007547956,0.1202666,0.002820836,0.005796805,0.00204725,0.0004965669,0.00162304,0.02564474,0.000532084,0.02767326,0.6121754],"study_design_scores_gemma":[0.1315892,0.1280401,0.6817265,0.0006475872,0.006190376,0.00623176,0.0005584611,0.001909132,0.007656592,0.0007426012,0.03455701,0.0001506519],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9613352,0.02322108,0.0004225141,0.002120231,0.0001731846,0.000358299,0.003533371,0.0001435481,0.00869264],"genre_scores_gemma":[0.9896772,0.00465563,0.0006966426,0.0007604572,0.0001189683,0.0001446634,0.002441156,0.0000312386,0.001474143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00321598,"threshold_uncertainty_score":0.01075846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02421671536513236,"score_gpt":0.2917548519157479,"score_spread":0.2675381365506155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}