{"id":"W4387362519","doi":"10.1210/jendso/bvad114.1457","title":"THU206 Constitutional Delay Of Puberty And Idiopathic Hypogonadotropic Hypogonadism: Differential Contributions Of Common Genetic Variants","year":2023,"lang":"en","type":"article","venue":"Journal of the Endocrine Society","topic":"Genetics and Physical Performance","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Genome-wide association study; Hypogonadotropic hypogonadism; Medicine; Imputation (statistics); Exome sequencing; Single-nucleotide polymorphism; Internal medicine; Bioinformatics; Genotype; Gynecology; Pediatrics; Genetics; Biology; Mutation; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004233307,0.000607336,0.0004782505,0.001113228,0.0006005149,0.0008333629,0.000633206,0.0006964228,0.009378807],"category_scores_gemma":[0.001989859,0.0002582683,0.0006662406,0.0015185,0.0005272635,0.0002355882,0.0006194781,0.0006487723,0.0004028342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002362655,"about_ca_system_score_gemma":0.0003305514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002701742,"about_ca_topic_score_gemma":0.003073135,"domain_scores_codex":[0.9994859,0.0001287565,0.00005225982,0.0001627102,0.00009418733,0.00007606267],"domain_scores_gemma":[0.9990989,0.0003649264,0.0002659749,0.00005230648,0.00003433354,0.0001836275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003830585,0.0001763803,0.9470431,0.000313089,0.0009220347,0.009923818,0.0005915932,0.0002917924,0.0111172,0.002203158,0.002070676,0.02151673],"study_design_scores_gemma":[0.0002111214,0.0004373098,0.9744888,0.0001506303,0.0004846666,0.01668942,0.0003751026,0.001110626,0.001219225,0.001696748,0.003098855,0.00003741628],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947333,0.001400494,0.0004859002,0.0003378372,0.00007550986,0.00003169915,0.001178548,0.00001948294,0.0017372],"genre_scores_gemma":[0.9969649,0.0003144794,0.0008085752,0.00008817451,0.00008528523,0.00002206405,0.0008989855,0.00001762878,0.0007998057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009378807,"threshold_uncertainty_score":0.03137529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007135217736103337,"score_gpt":0.2419718052022872,"score_spread":0.2348365874661839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}