{"id":"W4387363075","doi":"10.1371/journal.pbio.3002293","title":"A call to implement preclinical study registration in animal ethics review","year":2023,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Animal testing and alternatives","field":"Veterinary","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Canadian Council on Animal Care; University of Guelph; Ottawa Hospital; University of Ottawa","funders":"Ottawa Hospital Anesthesia Alternate Funds Association; Canadian Institutes of Health Research; Canadian Anesthesiologists' Society; Government of Ontario; University of Ottawa; Canadian Anesthesia Research Foundation","keywords":"Transparency (behavior); Biology; Trial registration; Animal testing; Protocol (science); Institutional review board; Preclinical research; Clinical trial; Research ethics; Research integrity; Medical physics; Bioinformatics; Engineering ethics; Computer science; Biotechnology; Pathology; Medicine; Alternative medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001299994,0.00009128432,0.0002275379,0.00005731572,0.00004161346,0.000006146697,0.0001414797,0.00006712387,0.00004997943],"category_scores_gemma":[0.00251893,0.00007644563,0.00003155627,0.000223007,0.00002327533,0.00002023434,0.0001498839,0.000310187,0.0002964767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002501334,"about_ca_system_score_gemma":0.0000385268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002206269,"about_ca_topic_score_gemma":0.0003070043,"domain_scores_codex":[0.9984571,0.0005277771,0.0003812697,0.0003324791,0.00008898466,0.0002124286],"domain_scores_gemma":[0.9990222,0.0006375949,0.00007356449,0.0001757674,0.00004486965,0.00004603295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001303604,0.002201003,0.9237299,0.001067673,0.0001931483,0.0007304651,0.006985088,0.000002431978,0.0408994,0.004214442,0.01133713,0.007335738],"study_design_scores_gemma":[0.001086437,0.03384351,0.9443936,0.001446189,0.00006377464,0.00003317375,0.0008000053,0.0004718292,0.0001320774,0.001043404,0.01620035,0.0004856307],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937583,0.000246895,0.00001096712,0.004645949,0.00005051296,0.0005956867,0.00001851537,0.0001265959,0.0005465887],"genre_scores_gemma":[0.9981803,0.0003135259,0.0002424217,0.0008792065,0.0001012441,0.000132156,0.00002847418,0.000009323612,0.000113314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04076732,"threshold_uncertainty_score":0.3810707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.7096417216719936,"score_gpt":0.5998346254616508,"score_spread":0.1098070962103428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}