{"id":"W4387379225","doi":"10.1021/acs.jmedchem.3c01482","title":"Superiority of the Triple-Acting 5-HT6R/5-HT3R Antagonist and MAO-B Reversible Inhibitor PZ-1922 over 5-HT6R Antagonist Intepirdine in Alleviation of Cognitive Deficits in Rats","year":2023,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Université de Montpellier; Narodowe Centrum Nauki; Fondation pour la Recherche Médicale; Agence Nationale de la Recherche","keywords":"Chemistry; Antagonist; 5-HT receptor; Serotonin; Monoamine oxidase A; Pharmacology; Monoamine oxidase; Receptor; Monoamine oxidase B; Antagonism; Monoamine neurotransmitter; Neuroscience; Internal medicine; Endocrinology; Psychology; Biochemistry; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004858019,0.0002595826,0.0002126287,0.0001244434,0.00006724027,0.0001279189,0.0002278712,0.0002359812,0.003030028],"category_scores_gemma":[0.00003374594,0.0001114018,0.0001676427,0.00006219273,0.00009929636,0.0002008492,0.0000671407,0.00041728,0.0004213308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001064916,"about_ca_system_score_gemma":0.0001487898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005422999,"about_ca_topic_score_gemma":0.0008463918,"domain_scores_codex":[0.9999758,0.000002292134,0.000002124178,0.00000519457,0.000006976685,0.000007507016],"domain_scores_gemma":[0.9999793,0.000003283689,0.000006259072,0.000002196737,0.000001842958,0.000007108189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004481877,0.0000536491,0.00006274446,0.00004300187,0.000008089681,0.00004259401,0.000005614113,0.0001086967,0.9968902,0.00009643741,0.0001085117,0.0021323],"study_design_scores_gemma":[0.00007197644,0.001560265,0.002399344,0.000004247593,0.00002673182,0.0002582346,0.00001357938,0.001763195,0.9920331,0.00006332996,0.001799357,0.000006590454],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914917,0.001308381,0.002909388,0.0001136184,0.00003180308,0.00003036177,0.0006632107,0.0002441832,0.003207351],"genre_scores_gemma":[0.9884719,0.001504694,0.004343193,0.00005845519,0.000009827113,0.00003433796,0.0006816371,0.00002840615,0.004867696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003030028,"threshold_uncertainty_score":0.01013649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02120487958034553,"score_gpt":0.2956464785460454,"score_spread":0.2744415989656998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}