{"id":"W4387380472","doi":"10.1210/jendso/bvad114.1771","title":"OR33-03 Circadian Analysis Of Nuclear Receptor Protein Expression In Mouse Liver Reveals Peak COUP-TFII, EAR2, LXRa, LXRb And TR4 Expression At The End Of The Mouse Active Cycle ZT0","year":2023,"lang":"en","type":"article","venue":"Journal of the Endocrine Society","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Nuclear receptor; Molecular biology; Chemistry; Circadian rhythm; Transcription factor; Mass spectrometry; Biology; Receptor; Chromatography; Biochemistry; Gene; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002563924,0.0004561648,0.0003449326,0.0008357454,0.0002619352,0.000517524,0.0003085189,0.0005527604,0.0140532],"category_scores_gemma":[0.0001079944,0.0002408442,0.000521503,0.0004564138,0.0003361983,0.0002861436,0.0002748194,0.0009965687,0.004272727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003641189,"about_ca_system_score_gemma":0.0002646571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007402138,"about_ca_topic_score_gemma":0.001866156,"domain_scores_codex":[0.9996179,0.00003772721,0.00002243464,0.00009258487,0.000110492,0.0001188982],"domain_scores_gemma":[0.9997569,0.0000177448,0.00006557108,0.00003216946,0.00002290818,0.0001047571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004309548,0.00004378741,0.0006375,0.00005083485,0.000009517449,0.0001054463,0.00001745175,0.00001781745,0.9950087,0.000124181,0.0005955081,0.002958396],"study_design_scores_gemma":[0.0001111416,0.001361939,0.1005245,0.00006459075,0.00005865136,0.00142483,0.0002005594,0.0007454581,0.873503,0.0001418836,0.02183896,0.00002443261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9486513,0.005916623,0.01180962,0.0006933222,0.0003077061,0.0001575493,0.01587766,0.0008090274,0.01577722],"genre_scores_gemma":[0.8942509,0.003890248,0.019849,0.000796994,0.0000954391,0.0005257583,0.02397147,0.0005369612,0.05608329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0140532,"threshold_uncertainty_score":0.04701263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005826038948943599,"score_gpt":0.2312513480635197,"score_spread":0.2254253091145761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}