{"id":"W4387382626","doi":"10.1200/po.23.00235","title":"Phase IIa Study of PLX2853 in Gynecologic Cancers With Known ARID1A Mutation and Phase Ib/IIa Study of PLX2853/Carboplatin in Platinum-Resistant Epithelial Ovarian Cancer","year":2023,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Carboplatin; Bromodomain; Medicine; Tolerability; ARID1A; Endometrial cancer; Ovarian cancer; Combination therapy; Internal medicine; Oncology; Phases of clinical research; Cancer; BET inhibitor; Clinical trial; Cancer research; Chemotherapy; Epigenetics; Mutation; Adverse effect; Cisplatin; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0022174,0.001338398,0.001815158,0.0005569769,0.0004814138,0.0007322388,0.0007571508,0.001594964,0.002446825],"category_scores_gemma":[0.0007094906,0.0007201648,0.0009861746,0.0004775231,0.001122592,0.000571305,0.0003410352,0.002322468,0.0005993462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000785889,"about_ca_system_score_gemma":0.001437141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006903845,"about_ca_topic_score_gemma":0.00173327,"domain_scores_codex":[0.9993457,0.0003430269,0.00004212884,0.00009911544,0.00004893808,0.0001209961],"domain_scores_gemma":[0.999293,0.0001042801,0.0001507785,0.0000688658,0.00004357314,0.0003394812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.53568,0.09324849,0.02276838,0.001305483,0.001450315,0.001189326,0.000569159,0.004770974,0.2174559,0.000890014,0.005364289,0.1153078],"study_design_scores_gemma":[0.3589225,0.6080378,0.01572836,0.00004870731,0.0003393141,0.0005941579,0.00009144474,0.001215528,0.01133601,0.0002556489,0.00340048,0.00002995589],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860278,0.002638291,0.0008589642,0.0004309588,0.00008238474,0.006687761,0.0008738287,0.00009315654,0.002306797],"genre_scores_gemma":[0.9888841,0.00138007,0.001924351,0.0006890831,0.0001185301,0.003444387,0.001545983,0.00002451722,0.001988977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002446825,"threshold_uncertainty_score":0.01172686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0235224428847283,"score_gpt":0.3537643563088148,"score_spread":0.3302419134240865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}