{"id":"W4387382626","doi":"10.1200/po.23.00235","title":"Phase IIa Study of PLX2853 in Gynecologic Cancers With Known ARID1A Mutation and Phase Ib/IIa Study of PLX2853/Carboplatin in Platinum-Resistant Epithelial Ovarian Cancer","year":2023,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Carboplatin; Bromodomain; Medicine; Tolerability; ARID1A; Endometrial cancer; Ovarian cancer; Combination therapy; Internal medicine; Oncology; Phases of clinical research; Cancer; BET inhibitor; Clinical trial; Cancer research; Chemotherapy; Epigenetics; Mutation; Adverse effect; Cisplatin; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007964087,0.000241309,0.000571297,0.000399973,0.00006532289,0.00001176721,0.0002038607,0.0002503168,0.00006015006],"category_scores_gemma":[0.0003419294,0.0002040884,0.00003404544,0.0006758661,0.0001152454,0.00001805986,0.0001691061,0.000207409,0.000001522914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001737362,"about_ca_system_score_gemma":0.0004387861,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002315163,"about_ca_topic_score_gemma":0.03146164,"domain_scores_codex":[0.9974554,0.0004754658,0.0008663142,0.0006129089,0.000295747,0.0002941984],"domain_scores_gemma":[0.998755,0.0001921028,0.0004829925,0.0003434529,0.0001426356,0.00008378027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.02029663,0.01760908,0.02890548,0.00007766704,0.0003077627,0.00037985,0.01278457,0.009932161,0.7217092,0.00003356069,0.0006579137,0.1873062],"study_design_scores_gemma":[0.2390521,0.2152998,0.2751091,0.0003691864,0.0003224946,0.00003388726,0.04236665,0.01324555,0.2074115,0.0003644145,0.004839748,0.001585518],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973571,0.0001393441,0.00005159083,0.00008776879,0.0002255292,0.001876147,0.00006796643,0.00001580739,0.0001787725],"genre_scores_gemma":[0.9990622,0.0001014771,0.0001878592,0.00003536864,0.00006264562,0.0003558853,0.00007079897,0.00002414133,0.00009963317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5142976,"threshold_uncertainty_score":0.9862117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0235224428847283,"score_gpt":0.3537643563088148,"score_spread":0.3302419134240865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}