{"id":"W4387385894","doi":"10.2139/ssrn.4591666","title":"The Splicing Factor SRSF6 Regulates AR and E2F Activity and Represents a Potential Therapeutic Target in Prostate Cancer","year":2023,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Prostate cancer; RNA splicing; Cancer; Downregulation and upregulation; Cancer research; Alternative splicing; Biology; Bioinformatics; Computational biology; Medicine; Genetics; Gene; Exon","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003725004,0.0002838584,0.000510245,0.0003026307,0.0001514943,0.0005780405,0.0002287347,0.0004463866,0.009734477],"category_scores_gemma":[0.0004083131,0.0001351132,0.0002432663,0.0004878059,0.0002287251,0.0003054464,0.0002434533,0.00059408,0.002907133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002723968,"about_ca_system_score_gemma":0.0002687628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003210038,"about_ca_topic_score_gemma":0.0003124939,"domain_scores_codex":[0.9998555,0.00002380077,0.000007717427,0.00002226362,0.00007315948,0.00001749797],"domain_scores_gemma":[0.9998903,0.00003218253,0.00002161253,0.00001851646,0.0000192426,0.00001814504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001949794,0.0001247259,0.006079153,0.001038266,0.0002117241,0.001848647,0.0001602608,0.004071866,0.5958341,0.04336756,0.02535391,0.3199598],"study_design_scores_gemma":[0.0002977446,0.0007311414,0.02037265,0.00008910752,0.000161738,0.007133329,0.000148816,0.01591891,0.6968791,0.04280153,0.2154168,0.00004926812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6692169,0.1110476,0.1242154,0.01171913,0.002276469,0.0001257865,0.009709391,0.00391943,0.06777],"genre_scores_gemma":[0.9238451,0.02222236,0.01760979,0.0004120344,0.000777129,0.00003373381,0.004441452,0.0004796898,0.03017874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009734477,"threshold_uncertainty_score":0.03256506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01235911804555313,"score_gpt":0.2943434122594387,"score_spread":0.2819842942138856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}