{"id":"W4387392976","doi":"10.1530/erc-23-0010","title":"Semaphorin 3C promotes de novo steroidogenesis in prostate cancer cells","year":2023,"lang":"en","type":"article","venue":"Endocrine Related Cancer","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Zymeworks (Canada); Vancouver General Hospital; University of British Columbia","funders":"Terry Fox Research Institute; Terry Fox Foundation; Michael Smith Health Research BC; Prostate Cancer Canada; Cancer Research Society; National Cancer Institute; National Institutes of Health; Prostate Cancer Foundation; U.S. Department of Defense","keywords":"Prostate cancer; Semaphorin; Androgen; LNCaP; Androgen receptor; Androgen deprivation therapy; Endocrinology; Internal medicine; Cancer research; Biology; Enzalutamide; Downregulation and upregulation; Cancer; Medicine; Hormone; Receptor; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002074886,0.0002764675,0.0004158207,0.000445382,0.00008245966,0.0000269598,0.0001297127,0.00008530224,0.0009504798],"category_scores_gemma":[0.00002792648,0.0002229218,0.0001130613,0.001663073,0.00008921412,0.0001066031,0.0000975666,0.0004548238,0.0002208006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008773103,"about_ca_system_score_gemma":0.0006828139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002380674,"about_ca_topic_score_gemma":0.000549225,"domain_scores_codex":[0.9976133,0.00007402118,0.0003808606,0.0005109485,0.0003974955,0.001023354],"domain_scores_gemma":[0.9991843,0.00006147313,0.00007361903,0.0003139702,0.0001110685,0.0002556063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001593686,0.0004519947,0.493645,0.001041057,0.000883048,0.008939618,0.003442022,0.00170913,0.4147422,0.00004657545,0.01205322,0.06145254],"study_design_scores_gemma":[0.01376454,0.0005238085,0.0866568,0.001479388,0.0002723706,0.0002155983,0.0004554758,0.001701116,0.8547172,0.0002817335,0.0392602,0.0006717867],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806502,0.009876923,7.256144e-7,0.006254877,0.0004063591,0.001194723,0.0001001126,0.000280468,0.001235557],"genre_scores_gemma":[0.9097947,0.03335673,0.00006569585,0.0001507769,0.0001849312,0.001452271,0.00008042993,0.0001002854,0.05481421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.439975,"threshold_uncertainty_score":0.9999628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02375680841031348,"score_gpt":0.343803389440908,"score_spread":0.3200465810305946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}