{"id":"W4387392976","doi":"10.1530/erc-23-0010","title":"Semaphorin 3C promotes de novo steroidogenesis in prostate cancer cells","year":2023,"lang":"en","type":"article","venue":"Endocrine Related Cancer","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Zymeworks (Canada); Vancouver General Hospital; University of British Columbia","funders":"Terry Fox Research Institute; Terry Fox Foundation; Michael Smith Health Research BC; Prostate Cancer Canada; Cancer Research Society; National Cancer Institute; National Institutes of Health; Prostate Cancer Foundation; U.S. Department of Defense","keywords":"Prostate cancer; Semaphorin; Androgen; LNCaP; Androgen receptor; Androgen deprivation therapy; Endocrinology; Internal medicine; Cancer research; Biology; Enzalutamide; Downregulation and upregulation; Cancer; Medicine; Hormone; Receptor; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007376235,0.0002036711,0.00024121,0.0002040292,0.000158324,0.0001911643,0.00009777067,0.0001681673,0.0008368986],"category_scores_gemma":[0.0000498237,0.00009655196,0.000250541,0.0002108185,0.0001494644,0.00006195063,0.0001259885,0.000534675,0.0002515525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003052703,"about_ca_system_score_gemma":0.0004720935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001658004,"about_ca_topic_score_gemma":0.003518428,"domain_scores_codex":[0.9999096,0.00001296877,0.000006147208,0.00001172292,0.00003358252,0.0000258004],"domain_scores_gemma":[0.9999578,0.000006626366,0.00000761318,0.000006507056,0.000005518886,0.00001595192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006728709,0.00003956619,0.0001918129,0.00002982386,0.00000571728,0.00003200151,0.000008815336,0.00005949736,0.9980226,0.00006502504,0.00007297051,0.001404801],"study_design_scores_gemma":[0.00002708397,0.0004132726,0.009265704,0.000004871896,0.00001991748,0.0002959365,0.00002337201,0.0008681099,0.9842681,0.00005721414,0.004751078,0.000005237924],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911006,0.003434922,0.001520939,0.0001770336,0.00005445376,0.00003342013,0.0004356961,0.0001496821,0.003093232],"genre_scores_gemma":[0.9947743,0.001295559,0.000892687,0.00008933516,0.000009636914,0.00002260216,0.0005242764,0.00001413947,0.002377488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001658004,"threshold_uncertainty_score":0.003296733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02375680841031348,"score_gpt":0.343803389440908,"score_spread":0.3200465810305946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}