{"id":"W4387393214","doi":"10.1007/s11864-023-01132-w","title":"Optimal Therapeutic Strategy for PD-L1 Negative Metastatic Non-Small Cell Lung Cancer: A Decision-Making Guide Based on Clinicopathological and Molecular Features","year":2023,"lang":"en","type":"review","venue":"Current Treatment Options in Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Durvalumab; Medicine; Atezolizumab; Pembrolizumab; Tremelimumab; Nivolumab; Ipilimumab; Oncology; Lung cancer; PD-L1; Internal medicine; Immunotherapy; Avelumab; Immune checkpoint; Blockade; Cancer; Chemotherapy; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001175548,0.0006521027,0.001614391,0.001039306,0.0002593681,0.001389511,0.0010159,0.001038556,0.002229393],"category_scores_gemma":[0.001625683,0.0002296269,0.0009468141,0.0005194873,0.0003617037,0.001361753,0.0005216942,0.002841049,0.0009054371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008309943,"about_ca_system_score_gemma":0.001543815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000852951,"about_ca_topic_score_gemma":0.002358975,"domain_scores_codex":[0.9996893,0.00009992011,0.00005607737,0.00005260632,0.00007495742,0.00002709326],"domain_scores_gemma":[0.9995527,0.0002649795,0.00006352185,0.000007388362,0.0000808885,0.00003054143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001380721,0.00007576189,0.0009807564,0.004922822,0.0001611476,0.0003175039,0.000048041,0.001079727,0.0009603135,0.003838842,0.03481067,0.9526664],"study_design_scores_gemma":[0.0003157534,0.0005668773,0.006116993,0.02680366,0.001586689,0.005554466,0.0003565782,0.00326715,0.00144698,0.03000049,0.9238499,0.0001343964],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006543988,0.9876733,0.003197881,0.005261818,0.0004959307,0.00004051319,0.0001061112,0.0000365522,0.002533456],"genre_scores_gemma":[0.01238192,0.9680107,0.01104964,0.004707634,0.001631315,0.0001389309,0.0004028307,0.00001475425,0.001662331],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002229393,"threshold_uncertainty_score":0.007458091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1479708577957534,"score_gpt":0.5008112849415937,"score_spread":0.3528404271458402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}