{"id":"W4387393214","doi":"10.1007/s11864-023-01132-w","title":"Optimal Therapeutic Strategy for PD-L1 Negative Metastatic Non-Small Cell Lung Cancer: A Decision-Making Guide Based on Clinicopathological and Molecular Features","year":2023,"lang":"en","type":"review","venue":"Current Treatment Options in Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Durvalumab; Medicine; Atezolizumab; Pembrolizumab; Tremelimumab; Nivolumab; Ipilimumab; Oncology; Lung cancer; PD-L1; Internal medicine; Immunotherapy; Avelumab; Immune checkpoint; Blockade; Cancer; Chemotherapy; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004913228,0.0006754781,0.002194089,0.0006009071,0.0001371216,0.00004067386,0.0001769557,0.0003998656,0.00005670927],"category_scores_gemma":[0.0001074661,0.0004597327,0.0008189575,0.0005174858,0.0001853893,0.00002659039,0.00004639796,0.0004845673,0.000007443744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00206328,"about_ca_system_score_gemma":0.001789183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002921702,"about_ca_topic_score_gemma":0.00008401492,"domain_scores_codex":[0.9969646,0.0004077691,0.001041068,0.0009086162,0.0001803178,0.0004975823],"domain_scores_gemma":[0.99548,0.003425349,0.0004692934,0.0004258462,0.0000872258,0.0001123019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001342697,0.001580067,0.00003413406,0.00312819,0.0004849097,0.0002323744,0.00009330335,0.0007779477,0.000001925131,0.00003676402,0.0005267342,0.991761],"study_design_scores_gemma":[0.01739315,0.01531675,0.0006316263,0.03784275,0.01176779,0.0001628443,0.0002711487,0.00629044,0.000008049599,0.0001970334,0.9090858,0.00103261],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001009677,0.9903722,0.001592724,0.0001210576,0.0005953896,0.005761355,0.0002841495,0.00005974117,0.0002036941],"genre_scores_gemma":[0.0004625343,0.9856017,0.006949009,0.000160206,0.0001189993,0.006177783,0.0003089433,0.00008206913,0.0001387046],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9907283,"threshold_uncertainty_score":0.9997854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1479708577957534,"score_gpt":0.5008112849415937,"score_spread":0.3528404271458402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}