{"id":"W4387393578","doi":"10.1093/cid/ciad607","title":"Food and Drug Administration Public Workshop Summary—Addressing Challenges in Inhaled Antifungal Drug Development","year":2023,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Center for Drug Evaluation and Research; U.S. Food and Drug Administration","keywords":"Medicine; Intensive care medicine; Clinical trial; Food and drug administration; Drug; Antifungal; Drug development; Clinical research; Antifungal drug; Antifungal drugs; Aspergillosis; Pharmacology; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0272425,0.002278349,0.0008425158,0.001236137,0.004402046,0.008989765,0.003746027,0.02116653,0.03610387],"category_scores_gemma":[0.01168264,0.0007032373,0.001680471,0.0006972446,0.001755704,0.00568139,0.006834945,0.01762137,0.01252453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005019273,"about_ca_system_score_gemma":0.0250808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004235873,"about_ca_topic_score_gemma":0.01022251,"domain_scores_codex":[0.9926057,0.001593067,0.0004464453,0.0006787213,0.002894106,0.001781986],"domain_scores_gemma":[0.9824206,0.003457901,0.001184786,0.0006026247,0.006740293,0.005593744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008593185,0.0003194879,0.0002506878,0.0001980528,0.00001343313,0.0003449497,0.0001224774,0.0001514413,0.00110582,0.001988224,0.9684734,0.02694612],"study_design_scores_gemma":[0.00006860355,0.0001562474,0.0008806938,0.0003055901,0.000012659,0.0001029879,0.000415376,0.0001621241,0.0004998178,0.00175442,0.9956129,0.00002865396],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.002003748,0.009068077,0.002223976,0.8984825,0.05953711,0.0008751152,0.0008147144,0.0002366355,0.02675819],"genre_scores_gemma":[0.02280621,0.01639042,0.007871114,0.6866834,0.07304385,0.001584499,0.001895144,0.0002570675,0.1894684],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.03610387,"threshold_uncertainty_score":0.1440738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1602374818250727,"score_gpt":0.3932907682398947,"score_spread":0.233053286414822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}