{"id":"W4387396627","doi":"10.1016/j.fertnstert.2023.08.266","title":"SINGLE-CELL TRANSCRIPTOMICS OF POST-IMPLANTATION HUMAN EMBRYOS REVEAL LINEAGE DYNAMICS AND PLOIDY-DEPENDENT SIGNATURES","year":2023,"lang":"en","type":"article","venue":"Fertility and Sterility","topic":"stochastic dynamics and bifurcation","field":"Physics and Astronomy","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"CReATe Fertility Centre; University of Toronto","funders":"","keywords":"Embryo; Epiblast; Biology; Embryonic stem cell; Zygote; Embryogenesis; Genetics; Cell biology; Transcriptome; Zona pellucida; Andrology; Gene; Gene expression; Oocyte; Gastrulation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002578257,0.0001399064,0.0002096884,0.00005327482,0.0001290645,0.00004217096,0.00007491426,0.00007307666,0.00001158033],"category_scores_gemma":[0.000007607034,0.0001345556,0.00005280647,0.0000910197,0.00007935736,0.00009929512,0.00005045604,0.0001294063,0.000001336063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002040896,"about_ca_system_score_gemma":0.00001903714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003804015,"about_ca_topic_score_gemma":0.0001695289,"domain_scores_codex":[0.999046,0.00005214342,0.0003164164,0.0002856644,0.0001305213,0.0001692444],"domain_scores_gemma":[0.99951,0.00005728173,0.0001015755,0.0001805572,0.00008326642,0.00006735526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.007720111,0.00188269,0.1391798,0.001708993,0.0002336188,0.000004822522,0.008366984,0.0002158507,0.7429852,0.005538872,0.00008303734,0.09207991],"study_design_scores_gemma":[0.0006196663,0.0001733373,0.970032,0.00002318177,0.00004111712,4.214432e-7,0.000962482,0.02054405,0.004365711,0.003067692,0.000008950165,0.0001613907],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920911,0.00002335672,0.006035325,0.00006541137,0.0001021406,0.0002431429,0.000804831,0.00003353758,0.0006011251],"genre_scores_gemma":[0.9990645,0.000001632825,0.0000846234,0.00002079008,0.00003283175,0.000008871521,0.0006049293,0.000009275296,0.0001725571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8308522,"threshold_uncertainty_score":0.5487017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01437282057731755,"score_gpt":0.240534498462969,"score_spread":0.2261616778856515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}