{"id":"W4387396627","doi":"10.1016/j.fertnstert.2023.08.266","title":"SINGLE-CELL TRANSCRIPTOMICS OF POST-IMPLANTATION HUMAN EMBRYOS REVEAL LINEAGE DYNAMICS AND PLOIDY-DEPENDENT SIGNATURES","year":2023,"lang":"en","type":"article","venue":"Fertility and Sterility","topic":"stochastic dynamics and bifurcation","field":"Physics and Astronomy","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"CReATe Fertility Centre; University of Toronto","funders":"","keywords":"Embryo; Epiblast; Biology; Embryonic stem cell; Zygote; Embryogenesis; Genetics; Cell biology; Transcriptome; Zona pellucida; Andrology; Gene; Gene expression; Oocyte; Gastrulation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001132946,0.00007983691,0.0001804613,0.0001943421,0.0001118623,0.000266988,0.00008650764,0.0002259392,0.0007630247],"category_scores_gemma":[0.0003101078,0.0001404635,0.0001213955,0.0002014409,0.000118929,0.0002070643,0.0001333042,0.0002335014,0.0002689401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001442285,"about_ca_system_score_gemma":0.0001115224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004781329,"about_ca_topic_score_gemma":0.0009590905,"domain_scores_codex":[0.999958,0.000004260938,0.000001887261,0.00001698058,0.00001174461,0.0000069915],"domain_scores_gemma":[0.999907,0.00004616087,0.00001850393,0.000007742455,0.00001283225,0.000007697214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00006984931,0.000003523676,0.005772651,0.00002561563,0.000007677751,0.00004950097,0.00006667598,0.0004905846,0.9888245,0.0002512546,0.00006692277,0.004371204],"study_design_scores_gemma":[0.0000139046,0.0001421473,0.5147223,0.00002174264,0.0000369105,0.0005787772,0.0002728479,0.01730078,0.4617171,0.001597831,0.003567874,0.00002764661],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871071,0.0009969355,0.009255236,0.00008645169,0.000006903374,0.00001083971,0.001607282,0.00004060423,0.0008885529],"genre_scores_gemma":[0.9941737,0.0007360302,0.00269756,0.00005332782,0.000007363384,0.00002574943,0.001076697,0.00002671997,0.001202962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007630247,"threshold_uncertainty_score":0.002552569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01437282057731755,"score_gpt":0.240534498462969,"score_spread":0.2261616778856515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}