{"id":"W4387397887","doi":"10.18632/aging.205090","title":"A SARS-CoV-2 related signature that explores the tumor microenvironment and predicts immunotherapy response in esophageal squamous cell cancer","year":2023,"lang":"en","type":"article","venue":"Aging","topic":"Esophageal Cancer Research and Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Yonsei University College of Medicine; Research Institute, Nationwide Children's Hospital; School of Medicine, Indiana University; University of Texas MD Anderson Cancer Center; National Institutes of Health; Keimyung University; University of Dundee; Chonnam National University; Hospital de Câncer de Barretos; Broad Institute; Pusan National University; Brown University; National Natural Science Foundation of China; Nationwide Children's Hospital; University of Pittsburgh; Memorial Sloan-Kettering Cancer Center; Johns Hopkins University; Peter MacCallum Cancer Centre; Van Andel Research Institute; Washington University in St. Louis; Sidney Kimmel Comprehensive Cancer Center; University of Rochester; Yonsei University; University of Southern California; BC Cancer Agency; Vanderbilt University; Case Western Reserve University; University of North Carolina at Chapel Hill; Brigham and Women's Hospital; Emory University; KU Leuven","keywords":"Nomogram; Gene signature; Medicine; Immunotherapy; Oncology; Malignancy; Esophageal cancer; Immune system; Cancer; Squamous cell cancer; Tumor microenvironment; Internal medicine; Computational biology; Gene; Immunology; Biology; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005683367,0.0003271024,0.0004241157,0.0008189853,0.0002308791,0.0005596413,0.0001472789,0.0002934366,0.001059656],"category_scores_gemma":[0.0009696005,0.00009436241,0.0004828865,0.0008841905,0.0001863659,0.0002031386,0.0003079606,0.0003178135,0.0002394107],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000354446,"about_ca_system_score_gemma":0.0003849854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009607588,"about_ca_topic_score_gemma":0.002099634,"domain_scores_codex":[0.9998054,0.00004766509,0.00001913811,0.00005769149,0.00003906454,0.0000309355],"domain_scores_gemma":[0.9995052,0.0001242177,0.0002045482,0.00003654282,0.00007658649,0.00005288482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008988941,0.0001002369,0.9230433,0.0002031943,0.0002116057,0.000246034,0.0001251001,0.00881779,0.03804931,0.0002567498,0.001178955,0.02686883],"study_design_scores_gemma":[0.00003165454,0.0004087004,0.9232515,0.00005907783,0.000277567,0.0008795392,0.0004249531,0.05849112,0.01174254,0.001159681,0.003233372,0.00004024533],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911471,0.0008600511,0.004770415,0.0001142775,0.00001357707,0.00004157795,0.002170644,0.00006450961,0.0008178272],"genre_scores_gemma":[0.9935906,0.0002043028,0.003363054,0.00005809207,0.00001240085,0.00003586513,0.002481666,0.00001213896,0.0002418454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001059656,"threshold_uncertainty_score":0.003544867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02574594941742348,"score_gpt":0.304538846230926,"score_spread":0.2787928968135025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}