{"id":"W4387397887","doi":"10.18632/aging.205090","title":"A SARS-CoV-2 related signature that explores the tumor microenvironment and predicts immunotherapy response in esophageal squamous cell cancer","year":2023,"lang":"en","type":"article","venue":"Aging","topic":"Esophageal Cancer Research and Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Yonsei University College of Medicine; Research Institute, Nationwide Children's Hospital; School of Medicine, Indiana University; University of Texas MD Anderson Cancer Center; National Institutes of Health; Keimyung University; University of Dundee; Chonnam National University; Hospital de Câncer de Barretos; Broad Institute; Pusan National University; Brown University; National Natural Science Foundation of China; Nationwide Children's Hospital; University of Pittsburgh; Memorial Sloan-Kettering Cancer Center; Johns Hopkins University; Peter MacCallum Cancer Centre; Van Andel Research Institute; Washington University in St. Louis; Sidney Kimmel Comprehensive Cancer Center; University of Rochester; Yonsei University; University of Southern California; BC Cancer Agency; Vanderbilt University; Case Western Reserve University; University of North Carolina at Chapel Hill; Brigham and Women's Hospital; Emory University; KU Leuven","keywords":"Nomogram; Gene signature; Medicine; Immunotherapy; Oncology; Malignancy; Esophageal cancer; Immune system; Cancer; Squamous cell cancer; Tumor microenvironment; Internal medicine; Computational biology; Gene; Immunology; Biology; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004538045,0.0001747471,0.0002060043,0.0001600761,0.0001234958,0.00003037016,0.0001037103,0.0000518659,0.00004158237],"category_scores_gemma":[0.0000274524,0.0001156391,0.00005539426,0.0003071951,0.0001109144,0.00007487832,0.00007778584,0.0003900478,0.00003359319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002394014,"about_ca_system_score_gemma":0.00009375914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004268728,"about_ca_topic_score_gemma":0.00005729866,"domain_scores_codex":[0.9985774,0.0001726295,0.0001690115,0.0003170579,0.0003276932,0.0004361708],"domain_scores_gemma":[0.9993452,0.0002395606,0.00004998405,0.0002846656,0.00001076583,0.00006978865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01202913,0.0005252648,0.3696245,0.0003559751,0.0003061045,0.01597212,0.0264579,0.0002516649,0.5546485,0.00002103311,0.007208117,0.01259969],"study_design_scores_gemma":[0.006413857,0.0006398948,0.70038,0.0002167253,0.00004487275,0.00007217524,0.0008441292,0.0004921631,0.2894569,0.0001349184,0.001146536,0.0001578581],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9503636,0.04377991,0.000001424918,0.004964566,0.00006428905,0.0006648276,0.00001608469,0.00007765193,0.00006758071],"genre_scores_gemma":[0.9958434,0.002102372,0.00002305998,0.0009458124,0.00003963019,0.0002392597,0.00001382683,0.00003948884,0.0007531216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3307554,"threshold_uncertainty_score":0.4715624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02574594941742348,"score_gpt":0.304538846230926,"score_spread":0.2787928968135025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}