{"id":"W4387400082","doi":"10.3390/curroncol30100653","title":"Double Duty: Complete Pathologic Response of Two Colonic Primaries with Mosaicism of a Novel MLH1 Mutation to Neoadjuvant Pembrolizumab","year":2023,"lang":"en","type":"article","venue":"Current Oncology","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Western University","funders":"","keywords":"MLH1; Pembrolizumab; Medicine; Mutation; Complete response; Neoadjuvant therapy; Cancer research; Pathological; Pathology; Internal medicine; Gene; Biology; Genetics; DNA mismatch repair; Colorectal cancer; Cancer; Chemotherapy; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002143036,0.0006089749,0.0004597243,0.0006728159,0.0006966791,0.0005193284,0.0004457329,0.00168239,0.002051091],"category_scores_gemma":[0.001475149,0.0003050594,0.0004717188,0.0002399539,0.0005297412,0.0004853901,0.0006781401,0.001134578,0.000605083],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004620166,"about_ca_system_score_gemma":0.0002452598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007304111,"about_ca_topic_score_gemma":0.001720251,"domain_scores_codex":[0.9997678,0.00002165657,0.00002180546,0.00006091097,0.00004652247,0.00008131845],"domain_scores_gemma":[0.9991721,0.0001764007,0.0001179994,0.00009747554,0.00004717207,0.0003888932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0002918909,0.00004089264,0.01196667,0.00004244249,0.00001605967,0.9722024,0.0001114076,0.0001162562,0.008257342,0.0001299452,0.0007294246,0.00609524],"study_design_scores_gemma":[0.00002463038,0.0001518175,0.0147117,0.0000100961,0.00001611262,0.9793839,0.00008487774,0.000396756,0.00307481,0.0001163936,0.002019614,0.000009401782],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804316,0.002002727,0.002837543,0.003764921,0.000572888,0.00009497231,0.0003413417,0.0001498965,0.009804043],"genre_scores_gemma":[0.9958338,0.0002825765,0.001030598,0.0005121995,0.000241452,0.000009477146,0.0001363089,0.00003201781,0.001921499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002051091,"threshold_uncertainty_score":0.006861567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1758596856046782,"score_gpt":0.431245199050155,"score_spread":0.2553855134454768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}