{"id":"W4387414183","doi":"10.2139/ssrn.4593223","title":"Safety and Efficacy of Inhaled IBIO123 for Severe COVID-19: A Randomised, Double-Blind, Dose-Ascending, Placebo-Controlled, Phase 1/2 Trial","year":2023,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Immune Biosolutions (Canada)","funders":"","keywords":"Double blind; Placebo; Coronavirus disease 2019 (COVID-19); Medicine; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Randomized controlled trial; 2019-20 coronavirus outbreak; Anesthesia; Phase (matter); Internal medicine; Virology; Physics; Pathology; Alternative medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001928223,0.002862379,0.006631833,0.000569888,0.0006827286,0.001753138,0.001456609,0.003816861,0.008914315],"category_scores_gemma":[0.002266424,0.001391263,0.002580051,0.0005296771,0.002333722,0.001737065,0.0006149011,0.004356339,0.00227139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000817141,"about_ca_system_score_gemma":0.001338678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009331666,"about_ca_topic_score_gemma":0.001493708,"domain_scores_codex":[0.9990265,0.0004390479,0.00005836156,0.0002123921,0.00008865278,0.0001750995],"domain_scores_gemma":[0.9990125,0.000261283,0.0002095849,0.0001106217,0.00007404217,0.0003318875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9882327,0.002782078,0.0001510317,0.0004383808,0.0005008947,0.00002386811,0.00002738319,0.0001007762,0.002232042,0.00006368083,0.0004219846,0.005025217],"study_design_scores_gemma":[0.970501,0.02814253,0.0004455238,0.0000215001,0.0002173527,0.00001520838,0.000009767343,0.0001166248,0.0001758253,0.00007165571,0.0002691143,0.00001382471],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753397,0.008927662,0.001412579,0.001022074,0.001139321,0.006714195,0.002050834,0.0002729031,0.003120729],"genre_scores_gemma":[0.9733843,0.005747695,0.002593302,0.001895036,0.0009687111,0.007473754,0.002039536,0.0001184389,0.005779339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008914315,"threshold_uncertainty_score":0.0298214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05395827669275308,"score_gpt":0.3688933692076771,"score_spread":0.314935092514924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}