{"id":"W4387417581","doi":"10.5267/j.ccl.2023.7.004","title":"Convenient and versatile method of 8-amino-6-(2-R-thiazol-4-yl)-1,7-naphthyridines synthesis","year":2023,"lang":"en","type":"article","venue":"Current Chemistry Letters","topic":"Synthesis of heterocyclic compounds","field":"Chemistry","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Enamine","keywords":"Chemistry; Thiazole; Trifluoromethanesulfonate; Halogenation; Pyrone; Aniline; Stereochemistry; Ammonia; Medicinal chemistry; Combinatorial chemistry; Organic chemistry; Catalysis","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001336246,0.0004260214,0.0002602656,0.0002490933,0.0002083204,0.0001256145,0.0003524336,0.0002842213,0.001243723],"category_scores_gemma":[0.00009027161,0.0001847802,0.0001607912,0.0001298028,0.0001485337,0.0002037572,0.0002519892,0.0004755101,0.0008972676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000165167,"about_ca_system_score_gemma":0.0002957532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002793936,"about_ca_topic_score_gemma":0.0008092695,"domain_scores_codex":[0.9998887,0.00001956174,0.000009186248,0.00002986857,0.00002982977,0.00002287795],"domain_scores_gemma":[0.9999558,0.00000529152,0.00001178796,0.000008278438,0.000009160304,0.000009725673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003359365,0.00002240949,0.00005594435,0.0002112824,0.000007084891,0.0001873577,0.00006492747,0.000208527,0.9899268,0.0007375463,0.0001746044,0.008369911],"study_design_scores_gemma":[0.00003213269,0.0003470877,0.0006166133,0.00001439937,0.00001449645,0.0008170482,0.00002132863,0.0007388046,0.9779599,0.0001692321,0.01924836,0.00002052145],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7727378,0.0229564,0.1647936,0.0004422756,0.0003394294,0.0009162254,0.001290301,0.001361582,0.03516243],"genre_scores_gemma":[0.9129108,0.00668428,0.06923728,0.00008862514,0.0000555389,0.0003934122,0.0005820102,0.00006994391,0.009978029],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001243723,"threshold_uncertainty_score":0.004160643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02341858931175894,"score_gpt":0.2805805282756306,"score_spread":0.2571619389638717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}