{"id":"W4387417611","doi":"10.5267/j.ccl.2023.8.003","title":"Multicomponent approach to the synthesis and spectral characterization of some 3,5-pyrazolididione derivatives and evaluation as anti-inflammatory agents","year":2023,"lang":"en","type":"article","venue":"Current Chemistry Letters","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Chemistry; Diethyl malonate; Phenylhydrazine; Pyrazolones; Yield (engineering); Pyrazolone; Imidazole; Pyrazole; Malononitrile; Catalysis; Organic chemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000297721,0.0001717784,0.000210376,0.00002446201,0.0001044288,0.00003420997,0.0001398425,0.00006404527,0.00006637168],"category_scores_gemma":[0.000221034,0.0001220647,0.00005113776,0.000100052,0.000102456,0.00008152244,0.0001151279,0.0001162681,0.000006695336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003945054,"about_ca_system_score_gemma":0.00001226491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003040788,"about_ca_topic_score_gemma":3.753424e-8,"domain_scores_codex":[0.9989118,0.00004114583,0.0002213282,0.0003499635,0.0002766157,0.0001991357],"domain_scores_gemma":[0.9994145,0.0001334977,0.000141577,0.0002006536,0.00002989209,0.00007986924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001840825,0.00008724973,0.005291487,0.0002738371,0.0000324186,5.445854e-7,0.0002116929,0.00001425165,0.9822238,0.000005405605,0.00002371943,0.01181717],"study_design_scores_gemma":[0.0001536024,0.000001081243,0.1429549,0.00008169517,0.00003845067,0.000003230017,0.0001012154,0.002434409,0.8539175,0.00001121448,0.0001594762,0.0001433107],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984031,0.00006863316,0.0000214912,0.00115392,0.00004906201,0.0001549006,0.00003321042,0.00004898056,0.00006668667],"genre_scores_gemma":[0.999383,0.0001861782,0.00001717084,0.00002933017,0.0001933119,0.00009499436,0.00008171088,0.00001091144,0.000003362547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1376634,"threshold_uncertainty_score":0.4977653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04432316017263485,"score_gpt":0.2715619159715176,"score_spread":0.2272387557988827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}