{"id":"W4387420637","doi":"10.1093/brain/awad345","title":"Machine learning nominates the inositol pathway and novel genes in Parkinson’s disease","year":2023,"lang":"en","type":"article","venue":"Brain","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital du Sacré-Cœur de Montréal; McGill University; Montreal Neurological Institute and Hospital","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Institutes of Health; Canada First Research Excellence Fund; McGill University; Fondation pour la Recherche Médicale; GlaxoSmithKline; Parkinson Society Canada; Killam Trusts; Consortium canadien en neurodégénérescence associée au vieillissement; Celgene; Pfizer; National Institute of Neurological Disorders and Stroke; Verily Life Sciences; Bristol-Myers Squibb; Sanofi; Michael J. Fox Foundation for Parkinson's Research","keywords":"LRRK2; Genome-wide association study; Parkinson's disease; Disease; Biology; Locus (genetics); Genetics; Candidate gene; Gene; Transcriptome; Genetic association; Neuroscience; Single-nucleotide polymorphism; Medicine; Mutation; Genotype; Gene expression; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002430028,0.00007489595,0.00007184228,0.0000658528,0.0001734452,0.00006816754,0.0001191388,0.00001981947,0.00003732246],"category_scores_gemma":[0.0004749876,0.00005284844,0.00002328057,0.0002487712,0.00005598153,0.00005984534,0.0001053529,0.000129718,0.00004835973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000871154,"about_ca_system_score_gemma":0.00001215626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000445527,"about_ca_topic_score_gemma":0.00001642982,"domain_scores_codex":[0.9993156,0.00009335238,0.00009376075,0.0002151798,0.0001051249,0.0001769598],"domain_scores_gemma":[0.9994401,0.0003830346,0.00002828765,0.00008696819,0.000003805112,0.00005780855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003823734,0.00004132848,0.05681711,0.00002219993,0.000001554541,0.00006514835,0.001153127,0.000421625,0.9039139,0.002943932,0.0005000928,0.03408177],"study_design_scores_gemma":[0.0009654571,0.00006724491,0.1459627,0.00007355929,0.000005550723,0.00001319014,0.0004308813,0.1383164,0.06654131,0.001080776,0.6461606,0.0003823848],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959995,0.0001709399,0.00002153309,0.003337426,0.00009020134,0.0001115602,0.000010559,0.00007250184,0.0001858079],"genre_scores_gemma":[0.9982444,0.00006917761,0.00001917418,0.0005840374,0.00004824198,0.00001044995,0.000002036091,0.00001608391,0.001006369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8373725,"threshold_uncertainty_score":0.2155097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02866717713946219,"score_gpt":0.2457440789983718,"score_spread":0.2170769018589096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}