{"id":"W4387421950","doi":"10.1016/j.jcyt.2023.09.001","title":"Failure to launch commercially-approved mesenchymal stromal cell therapies: what's the path forward? Proceedings of the International Society for Cell & Gene Therapy (ISCT) Annual Meeting Roundtable held in May 2023, Palais des Congrès de Paris, Organized by the ISCT MSC Scientific Committee","year":2023,"lang":"en","type":"article","venue":"Cytotherapy","topic":"Mesenchymal stem cell research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Rehabilitation Institute; University of Toronto; University Health Network","funders":"","keywords":"Mesenchymal stem cell; Medicine; Clinical trial; Cell therapy; Cell; Internal medicine; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02395974,0.000904242,0.001039327,0.0007757125,0.001824438,0.01017743,0.001601229,0.005829365,0.01230039],"category_scores_gemma":[0.0128251,0.0002985644,0.001169083,0.0004916136,0.002590839,0.005354677,0.002175806,0.00959263,0.005081057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003097342,"about_ca_system_score_gemma":0.006500465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003219121,"about_ca_topic_score_gemma":0.006591586,"domain_scores_codex":[0.9932328,0.001958294,0.0005170355,0.0006989968,0.002768406,0.000824491],"domain_scores_gemma":[0.9857362,0.005080909,0.001260926,0.0005073386,0.005122087,0.002292562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004136896,0.0003145504,0.002375189,0.002039743,0.0001377633,0.0004817625,0.0007644841,0.0007047316,0.01598767,0.01776945,0.496124,0.462887],"study_design_scores_gemma":[0.00004949464,0.0005417739,0.002008121,0.001308201,0.00008474914,0.000318302,0.001882463,0.0003240492,0.0058017,0.006207208,0.9813811,0.00009286105],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01077931,0.1468793,0.009915202,0.7749467,0.03708446,0.0002557125,0.0004756408,0.0004224491,0.01924109],"genre_scores_gemma":[0.12509,0.3337717,0.02610981,0.3864661,0.03278211,0.0008090021,0.001949746,0.0009994946,0.09202211],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02395974,"threshold_uncertainty_score":0.1267127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03714219479250224,"score_gpt":0.3064508967969202,"score_spread":0.2693087020044179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}