{"id":"W4387424812","doi":"10.1007/s00277-023-05483-0","title":"Predictors for improvement in patient-reported outcomes: post hoc analysis of a phase 3 randomized, open-label study of eculizumab and ravulizumab in complement inhibitor-naive patients with paroxysmal nocturnal hemoglobinuria","year":2023,"lang":"en","type":"article","venue":"Annals of Hematology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"Alexion Pharmaceuticals; Universität Ulm; AstraZeneca","keywords":"Paroxysmal nocturnal hemoglobinuria; Medicine; Eculizumab; Internal medicine; Post-hoc analysis; Hematology; Hemoglobinuria; Quality of life (healthcare); Randomized controlled trial; Anemia; Physical therapy; Immunology; Complement system; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007154488,0.0009675486,0.002214962,0.000272041,0.0003505709,0.001008233,0.000700358,0.0009514894,0.002163701],"category_scores_gemma":[0.005881955,0.0004009316,0.003680155,0.0003336622,0.0007102733,0.0009538225,0.000549487,0.002090786,0.0002215503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006555664,"about_ca_system_score_gemma":0.0009716293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003588534,"about_ca_topic_score_gemma":0.0007365359,"domain_scores_codex":[0.9951793,0.003275563,0.0002668475,0.0005816984,0.000328146,0.0003685094],"domain_scores_gemma":[0.9920649,0.004390385,0.001682548,0.0006879831,0.0003286121,0.0008455404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9272605,0.006809247,0.04516608,0.0001794434,0.005806735,0.00008042666,0.0001079035,0.001072082,0.00287891,0.00005971322,0.0004632965,0.01011552],"study_design_scores_gemma":[0.2517237,0.365809,0.3573274,0.00004444375,0.009606688,0.0002107535,0.0001995612,0.01000773,0.003627229,0.0003212572,0.001016153,0.0001061556],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988948,0.0002918392,0.0001698817,0.00004302428,0.00003312569,0.0001814467,0.0002260432,0.000007321675,0.0001527081],"genre_scores_gemma":[0.9983273,0.00009756278,0.0003580041,0.00008708925,0.00006212135,0.0003424546,0.000503392,0.000005402719,0.0002167733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007154488,"threshold_uncertainty_score":0.03783703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0430836626147483,"score_gpt":0.3498776452815406,"score_spread":0.3067939826667924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}