{"id":"W4387425886","doi":"10.1161/jaha.122.029090","title":"Association Between Whole Blood–Derived Mitochondrial DNA Copy Number, Low‐Density Lipoprotein Cholesterol, and Cardiovascular Disease Risk","year":2023,"lang":"en","type":"article","venue":"Journal of the American Heart Association","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"National Center for Advancing Translational Sciences; National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Human Genome Research Institute; National Institute on Aging; University of Texas Health Science Center at San Antonio; Kaiser Foundation Research Institute; Mississippi State Department of Health; Baylor University; Evans Medical Foundation; University of North Carolina at Chapel Hill; Broad Institute; Jackson State University; Johns Hopkins University; University of Washington; University of Texas Health Science Center at Houston; National Heart, Lung, and Blood Institute; Northwestern University; Feinberg School of Medicine; School of Medicine, Boston University; National Institute on Minority Health and Health Disparities; McGill University; Faculty of Medicine and Health, University of Sydney; University of Minnesota; Department of Epidemiology, Biostatistics and Occupational Health, McGill University; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Medicine; Disease; Cholesterol; Atherosclerotic cardiovascular disease; Ldl cholesterol; Internal medicine; Mitochondrial DNA; Lipoprotein; High-density lipoprotein; Cardiology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001759716,0.0002647765,0.0003072336,0.0006316605,0.0003169973,0.0004831969,0.0004765064,0.0003495442,0.001573473],"category_scores_gemma":[0.005114081,0.0002024633,0.0002924365,0.0006260056,0.0004032139,0.0002394731,0.0003432115,0.0003484257,0.0001213384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001803072,"about_ca_system_score_gemma":0.0002350123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001681976,"about_ca_topic_score_gemma":0.001609549,"domain_scores_codex":[0.9992698,0.0002560014,0.00006326655,0.0002454091,0.00009733384,0.00006828465],"domain_scores_gemma":[0.9963635,0.001487092,0.00119754,0.0004930242,0.000246489,0.0002125368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004390503,0.0000258064,0.9950665,0.00001710377,0.0002560437,0.00002895571,0.00003479572,0.0001608576,0.002115032,0.00005781019,0.00004483567,0.001753229],"study_design_scores_gemma":[0.0000156785,0.0001209601,0.9976024,0.000006003329,0.0001483252,0.0002249289,0.00003119723,0.0006718244,0.0008062338,0.0002219834,0.0001446113,0.00000582879],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980107,0.0003181395,0.0009405047,0.00003884446,0.000006057926,0.000008597249,0.0004817825,0.000009032104,0.0001863645],"genre_scores_gemma":[0.9987963,0.00008292599,0.0007093283,0.00001890996,0.000009897591,0.000014166,0.0002645004,0.000003575302,0.0001003951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001759716,"threshold_uncertainty_score":0.009306431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007662010679100511,"score_gpt":0.2347777888043389,"score_spread":0.2271157781252383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}