{"id":"W4387439283","doi":"10.1158/1078-0432.ccr-23-0229","title":"Comprehensive Single-Cell Immune Profiling Defines the Patient Multiple Myeloma Microenvironment Following Oncolytic Virus Therapy in a Phase Ib Trial","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"National Cancer Institute; L. K. Whittier Foundation","keywords":"Medicine; Multiple myeloma; Oncolytic virus; Bone marrow; Immune system; Bortezomib; Cytotoxic T cell; Thalidomide; Cytokine; Immunology; Tumor microenvironment; Dexamethasone; Internal medicine; Cancer research; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001107526,0.000538118,0.0009136421,0.0002230252,0.0002465829,0.000837985,0.0004158677,0.0005752029,0.001466463],"category_scores_gemma":[0.0004734606,0.0002019882,0.000408702,0.0002479285,0.0004066942,0.0005424008,0.0002766615,0.001705184,0.000352805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006139035,"about_ca_system_score_gemma":0.0007012606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002054384,"about_ca_topic_score_gemma":0.0005233445,"domain_scores_codex":[0.9996705,0.0001266563,0.00002103444,0.00006458395,0.0000485992,0.0000685917],"domain_scores_gemma":[0.9997074,0.00003257876,0.00008375943,0.00003812114,0.00001964527,0.0001184893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2837929,0.04126908,0.03271329,0.0007072454,0.0009439179,0.0002627638,0.000534709,0.004880275,0.3935926,0.0005827007,0.003241214,0.2374793],"study_design_scores_gemma":[0.1443334,0.6494015,0.09026007,0.0001238559,0.0008120273,0.00156274,0.0002208549,0.005482335,0.09388319,0.0007441437,0.01311329,0.00006268903],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956406,0.001596342,0.0005865867,0.0001215831,0.00002785091,0.0008212824,0.000254242,0.00004207476,0.000909382],"genre_scores_gemma":[0.9968143,0.0003982867,0.0008812282,0.0001992036,0.0000285525,0.0006743907,0.0005323322,0.000009871472,0.0004619035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001466463,"threshold_uncertainty_score":0.005857229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2025749589462749,"score_gpt":0.4697949480140262,"score_spread":0.2672199890677514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}