{"id":"W4387439518","doi":"10.1001/jamaneurol.2023.3542","title":"Efficacy and Safety of XEN1101, a Novel Potassium Channel Opener, in Adults With Focal Epilepsy","year":2023,"lang":"en","type":"article","venue":"JAMA Neurology","topic":"Epilepsy research and treatment","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"York University","keywords":"Medicine; Placebo; Adverse effect; Epilepsy; Randomized controlled trial; Clinical endpoint; Clinical trial; Anesthesia; Pediatrics; Internal medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002032257,0.0001373683,0.0003743727,0.0002017695,0.00003049302,0.000005580686,0.00007896119,0.0001494906,0.00002584209],"category_scores_gemma":[0.0001858414,0.00009874815,0.00003227895,0.000408045,0.0001723763,0.00004565739,0.0001123016,0.0003882039,0.00002779274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000126011,"about_ca_system_score_gemma":0.00008381584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001749903,"about_ca_topic_score_gemma":0.0002040624,"domain_scores_codex":[0.9987218,0.00007849637,0.0002327955,0.0003597465,0.0001961548,0.0004109711],"domain_scores_gemma":[0.9991569,0.0002988973,0.00005254226,0.0002559826,0.00005405383,0.000181632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1351128,0.003302823,0.8018072,0.0006580532,0.0003442048,0.007680316,0.001543265,0.0002387327,0.005277258,0.001294341,0.002800696,0.03994031],"study_design_scores_gemma":[0.02331789,0.006497872,0.9670958,0.00009452525,0.00002398655,0.0002867994,0.00003690779,0.001486883,0.0003345326,0.0000418688,0.0007055484,0.00007737019],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846543,0.0001081172,0.00001747094,0.01341896,0.00005042892,0.0006381106,0.00002751903,0.00003937711,0.001045721],"genre_scores_gemma":[0.9984423,0.000354585,0.00006812179,0.0007663771,0.00007651827,0.00006345879,0.00005172983,0.00002241592,0.0001545204],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1652886,"threshold_uncertainty_score":0.4026833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01920300058213239,"score_gpt":0.2789991152238699,"score_spread":0.2597961146417375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}