{"id":"W4387439518","doi":"10.1001/jamaneurol.2023.3542","title":"Efficacy and Safety of XEN1101, a Novel Potassium Channel Opener, in Adults With Focal Epilepsy","year":2023,"lang":"en","type":"article","venue":"JAMA Neurology","topic":"Epilepsy research and treatment","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"York University","keywords":"Medicine; Placebo; Adverse effect; Epilepsy; Randomized controlled trial; Clinical endpoint; Clinical trial; Anesthesia; Pediatrics; Internal medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000746503,0.0004388449,0.000612392,0.0001422952,0.0001314799,0.0003061135,0.000235951,0.0005743516,0.002372404],"category_scores_gemma":[0.0008354811,0.0001709657,0.0003705831,0.0001242158,0.0003254653,0.0005190287,0.0001815077,0.00083917,0.0003106043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002698563,"about_ca_system_score_gemma":0.0003468169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002184028,"about_ca_topic_score_gemma":0.0008611846,"domain_scores_codex":[0.9997931,0.00009371231,0.00002799469,0.00002960768,0.00003088521,0.00002472184],"domain_scores_gemma":[0.9996171,0.00009950723,0.0001707088,0.00001542684,0.00002523708,0.00007195447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5470363,0.02094183,0.02248437,0.003159367,0.001304387,0.0003607978,0.0002300438,0.000831502,0.054579,0.000264732,0.002646521,0.3461611],"study_design_scores_gemma":[0.2779903,0.634242,0.07260367,0.000179728,0.000942854,0.0009980734,0.0001365029,0.00101152,0.007954243,0.0002108946,0.00369943,0.00003078809],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932297,0.004818842,0.000180165,0.0002497698,0.0000433763,0.0002819545,0.0002153927,0.00003069888,0.0009500321],"genre_scores_gemma":[0.9959872,0.002220814,0.0003874448,0.0003162627,0.00008574309,0.0002146412,0.000215094,0.000003063903,0.000569724],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002372404,"threshold_uncertainty_score":0.007936537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01920300058213239,"score_gpt":0.2789991152238699,"score_spread":0.2597961146417375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}