{"id":"W4387439793","doi":"10.15252/emmm.202317761","title":"NRF3 suppresses squamous carcinogenesis, involving the unfolded protein response regulator HSPA5","year":2023,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Swiss Cancer Research Foundation; Université de Lausanne; Eidgenössische Technische Hochschule Zürich; Wilhelm Sander-Stiftung; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Regulator; Unfolded protein response; Chemistry; Carcinogenesis; Cell biology; Cancer research; Biology; Apoptosis; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008444345,0.0002503428,0.0002122651,0.0001578442,0.000130327,0.0001370677,0.0001003048,0.0001521856,0.001103334],"category_scores_gemma":[0.00006044931,0.000060737,0.0002378883,0.00008498226,0.0001258402,0.0001226536,0.0001173719,0.0002915193,0.0001650236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001187249,"about_ca_system_score_gemma":0.0001572279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003917918,"about_ca_topic_score_gemma":0.001180744,"domain_scores_codex":[0.9999577,0.000009735343,0.00000541244,0.000007066723,0.000008877039,0.00001132832],"domain_scores_gemma":[0.9999622,0.000003639875,0.0000110769,0.00000564842,0.000005339214,0.00001205971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006023891,0.00009941757,0.0002148614,0.00007366796,0.00001546525,0.00004361266,0.000009296535,0.00006431559,0.9954064,0.00008349227,0.00008052662,0.003306535],"study_design_scores_gemma":[0.00007122364,0.001604799,0.008144759,0.00001284785,0.00004749072,0.0002956139,0.00004641317,0.0006775683,0.9853671,0.000107107,0.003620144,0.000005039733],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944633,0.002589303,0.001246766,0.0001439979,0.00003666004,0.00002569778,0.0003620221,0.0001256581,0.001006573],"genre_scores_gemma":[0.9968645,0.001031913,0.0006377018,0.00004385402,0.000005654805,0.00001330459,0.0002280283,0.000008372879,0.001166635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001103334,"threshold_uncertainty_score":0.003691018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01930637599972397,"score_gpt":0.2966758034551271,"score_spread":0.2773694274554031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}