{"id":"W4387440486","doi":"10.15252/embr.202357014","title":"UBR‐1 ubiquitin ligase regulates the balance between GABAergic and glutamatergic signaling","year":2023,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Major International Joint Research Programme; National Institutes of Health; National Natural Science Foundation of China; Foundation for Innovative Research Groups of the National Natural Science Foundation of China; Scheme for Promotion of Academic and Research Collaboration; National Key Research and Development Program of China; Canadian Institutes of Health Research; China Scholarship Council","keywords":"Glutamatergic; GABAergic; Glutamate receptor; Cell biology; Ubiquitin ligase; Biology; Chemistry; Biochemistry; Neuroscience; Inhibitory postsynaptic potential; Ubiquitin; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008173614,0.0001573811,0.0001928813,0.0001034837,0.0003540804,0.0001781181,0.0002255556,0.0000672535,0.0001097905],"category_scores_gemma":[0.000514837,0.0001123762,0.00006086496,0.0005794717,0.0002135385,0.00009103197,0.0002801654,0.0001970677,0.00008638544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002111512,"about_ca_system_score_gemma":0.0000503054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000230534,"about_ca_topic_score_gemma":0.000001401403,"domain_scores_codex":[0.9979348,0.0001352643,0.0003484523,0.0005348549,0.0005413248,0.000505358],"domain_scores_gemma":[0.998777,0.0004256246,0.0001279957,0.0004704098,0.00003758063,0.0001613409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007835825,0.00001102828,0.02278273,0.00003087176,0.000006429445,0.0009084943,0.0003942117,0.00009300018,0.9734307,0.00005662128,0.001395219,0.000882845],"study_design_scores_gemma":[0.00008872093,0.00003758119,0.01614218,0.00003348241,0.000007528782,0.0002003733,0.00004579297,0.0005162221,0.9764547,0.00248117,0.003843252,0.0001490026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971032,0.0001281747,0.000004512031,0.0004583942,0.000244073,0.0002682129,0.00001310504,0.0001786187,0.001601689],"genre_scores_gemma":[0.9976293,0.0001493516,0.00002203198,0.0001323598,0.0002039229,0.00003603485,0.000008433809,0.00002935186,0.001789211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006640555,"threshold_uncertainty_score":0.458257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0479940155054051,"score_gpt":0.3101505583153074,"score_spread":0.2621565428099023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}