{"id":"W4387440992","doi":"10.1183/13993003.00714-2023","title":"Novel insights into the whole-blood DNA methylome of asthma in ethnically diverse children and youth","year":2023,"lang":"en","type":"article","venue":"European Respiratory Journal","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Chicoutimi; St. Michael's Hospital","funders":"National Institute of Environmental Health Sciences; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; Robert Wood Johnson Foundation; Instituto de Salud Carlos III; National Institutes of Health; Allergopharma; European Academy of Allergy and Clinical Immunology; European Regional Development Fund; American Asthma Foundation; Ministerio de Ciencia e Innovación; GlaxoSmithKline; Agencia Estatal de Investigación; National Institute on Minority Health and Health Disparities; Tobacco-Related Disease Research Program","keywords":"dNaM; DNA methylation; Asthma; Epigenetics; Epigenomics; Immunology; Exhaled nitric oxide; Biology; Transcriptome; Differentially methylated regions; Immune system; CpG site; Medicine; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002595893,0.0001631327,0.0002703724,0.000462732,0.0001955926,0.000386699,0.0001865062,0.0002331812,0.001716181],"category_scores_gemma":[0.000437274,0.0001121018,0.0002126171,0.0005383121,0.0001657934,0.0002008936,0.0003988493,0.0002795338,0.000168763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001966945,"about_ca_system_score_gemma":0.0002444343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00327476,"about_ca_topic_score_gemma":0.007012635,"domain_scores_codex":[0.9998906,0.00001901557,0.00000522961,0.00004578399,0.00001742486,0.00002203065],"domain_scores_gemma":[0.9998615,0.00003091417,0.00004650749,0.00001220661,0.00002184113,0.00002710836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005411325,0.00004638364,0.76787,0.0003195484,0.0002502392,0.0004006665,0.001281713,0.000428645,0.1615124,0.0006441407,0.001057778,0.0656473],"study_design_scores_gemma":[0.000008478146,0.0001031849,0.9884683,0.00003884895,0.00009591723,0.000553098,0.0005793778,0.0004225463,0.004994935,0.0007093103,0.004018304,0.000007747909],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860374,0.004973145,0.002862382,0.0004351762,0.00001473152,0.00001810105,0.004207531,0.00004832811,0.001403119],"genre_scores_gemma":[0.9912854,0.002391808,0.003063432,0.0003546352,0.00003018858,0.00003812375,0.001873089,0.00002076072,0.0009425466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00327476,"threshold_uncertainty_score":0.00651139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02473899586510329,"score_gpt":0.2611015780998759,"score_spread":0.2363625822347726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}